PMID: 8611456Apr 1, 1996Paper

Evidence for an active fibrinolytic system in normal human bone marrow

British Journal of Haematology
N McWilliamN A Booth

Abstract

Normal human bone marrow from patients undergoing heart surgery was analysed quantitatively for components of the fibrinolytic system, using functional and immunological assays. Marrow was found to contain considerable fibrinolytic activity, reflecting high levels of t-PA (tissue-type plasminogen activator). The t-PA was in an active form, despite the presence of the inhibitors PAI-1 and PAI-2. Plasminogen and alpha2-antiplasmin (alpha2-AP) were also present in marrow. The balance of proteases and inhibitors differed dramatically from that observed in plasma, with higher levels of t-PA, PAI-1 and PAI-2, and lower levels of u-PA (urokinase), plasminogen, alpha2-AP and t-PA-PAI-1 complex in bone marrow, and resulted in favourable conditions for fibrinolysis. The presence of plasmin-alpha2-AP complex at concentrations of the same order of magnitude as total plasminogen and alpha2-AP demonstrated that active generation of plasmin was indeed occurring. A role for the active fibrinolytic system in normal human bone marrow may be the removal of unnecessary fibrin deposits formed in the cavities of the marrow, in order to maintain flow through this tissue.

Citations

Jul 23, 1998·British Journal of Haematology·N McWilliamB Bennett
Dec 21, 2000·British Journal of Haematology·L RobbieB Bennett
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S MustjokiA Vaheri
Apr 19, 2007·Journal of Thrombosis and Haemostasis : JTH·M ErenD E Vaughan
Feb 15, 2002·Reviews in Clinical and Experimental Hematology·H G WatsonM Greaves
Dec 17, 2017·American Journal of Hematology·Orly LeivaKatya Ravid
Aug 28, 2003·Journal of Thrombosis and Haemostasis : JTH·N J MutchN A Booth
Apr 10, 2020·Cells·Christina M Ward, Katya Ravid
Dec 16, 2020·Blood Reviews·Ishnoor SidhuAnilkumar Gopalakrishnapillai

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