Evidence for an association between type 1 diabetes and premature carotid atherosclerosis in childhood.

Pediatric Cardiology
M E AtabekH Imamoglu

Abstract

Acute phase proteins have been suggested to be increased in patients with type 1 diabetes. The aim of this study was to evaluate the relationship between serum C-reactive protein (CRP) and intima-media thickness (IMT) and functions of the common carotid artery (CCA) in children and adolescents with type 1 diabetes. Serum CRP levels were measured in 65 children and adolescents with diabetes (33 girls and 32 boys; mean age, 12.7 +/- 3.8 years; range, 7-18; duration of diabetes, 6.9 +/- 3.6 years). Age and diabetes duration, as well as major cardiovascular risk factors including anthropometric and metabolic parameters, were matched between girls and boys. The relations of serum CRP levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance, cross-sectional distensibility, diastolic wall stress (DWS), and incremental elastic modulus (IEM). There was no significant difference for serum CRP levels between girls and boys (3.7 +/- 1.3 vs 3.2 +/- 0.4 mg/L; p > 0.05). CRP was positively correlated with IMT (r = 0.49, p = 0.001), IEM (r = 0.24, p = 0.05), DWS (r = 0.58, p < 0.001), and body mass index (BMI) (r = 0.28, p = 0.05). In a multivariate regression model, we included CRP and metaboli...Continue Reading

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Citations

Apr 25, 2012·Journal of Cardiovascular Translational Research·Janet K Snell-Bergeon, Kristen Nadeau
Dec 19, 2009·BMC Pediatrics·UNKNOWN Adolescent type 1 Diabetes cardio-renal Intervention Trial Research Group
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Jun 12, 2009·Pediatric Diabetes·Robert Dalla PozzaSusanne Bechtold
Apr 22, 2015·Journal of Diabetes and Its Complications·Yi-Peng SunHai-Feng Pan
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Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Rachel Becker-CohenYaacov Frishberg
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Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Robert Dalla PozzaHans-Peter Schwarz
Feb 22, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·María Mercedes PradoTomás Meroño

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