PMID: 2113082Jul 1, 1990Paper

Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide

Journal of Neurochemistry
S MurphyD G Harrison

Abstract

To determine whether astrocytes release nonprostanoid vasodilators, cells on microcarrier beads were superfused with various agents in the presence of indomethacin, and the effluent was bioassayed and also analyzed for nitric oxide by a chemiluminescence technique. Bradykinin and A23187 induced release of a factor that relaxed arterial rings, an effect that was blocked by hemoglobin. The effluent contained either nitric oxide or a related compound that could be reduced to nitric oxide. Production of this factor was competitively inhibited by the arginine analogs NG-nitro-L-arginine and NG-methyl-L-arginine and could be restored with L-arginine. Quisqualate and norepinephrine were also effective in causing the release of nitric oxide from astroglial cells. Thus, astrocyte-derived relaxing factor has properties similar to those of an endothelium- and neuron-derived relaxing factor.

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Citations

Sep 1, 1992·Annals of Neurology·T M DawsonS H Snyder
Sep 11, 1992·Journal of Neuroscience Research·J L RaszkiewiczS P Arneric
Feb 15, 1994·Journal of Neuroscience Research·E GaleaD L Feinstein
Jan 1, 1994·Medicinal Research Reviews·J F Kerwin, M Heller
Jan 1, 1994·Journal of Molecular Neuroscience : MN·J R Sparrow
Jul 24, 1995·Brain Research·L AgullóA García
Jan 1, 1992·Pharmacology & Therapeutics·F M Faraci
Aug 1, 1993·Trends in Neurosciences·S MurphyJ P Schwartz
Jan 1, 1994·Sheng li ke xue jin zhan [Progress in physiology]·J Q CuiH X Wagn
Jan 1, 1995·Bio Systems·M S Cooper
May 14, 1993·Neuroscience Letters·M EndohJ A Wagner
Jan 1, 1995·Brain Research Bulletin·N T SandorB Lendvai
May 1, 1991·Journal of the American College of Cardiology·D G Harrison
Mar 31, 2004·Molecular Aspects of Medicine·Juan P BolañosAngeles Almeida
Feb 23, 1999·Life Sciences·A Christopoulos, E E El-Fakahany
Apr 29, 1998·Brain Research. Molecular Brain Research·J M García-Barcina, C Matute
May 22, 2002·Neurochemistry International·I SuárezB Fernández
Aug 24, 1999·Neurochemistry International·P Sándor
Oct 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T SiegalH Ovadia
Jan 1, 1996·Free Radical Biology & Medicine·J P BolañosJ B Clark
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E GaleaD J Reis

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