Dec 6, 2000

Evidence for an evolutionary conserved role of bone morphogenetic protein growth factors and phox2 transcription factors during noradrenergic differentiation of sympathetic neurons. Induction of a putative synexpression group of neurotransmitter-synthesizing enzymes

European Journal of Biochemistry
U Ernsberger

Abstract

The noradrenergic transmitter phenotype in postganglionic sympathetic neurons is induced early during embryonic development in avian and mammalian primary sympathetic ganglia. The simultaneous expression of tyrosine hydroxylase and dopamine beta-hydroxylase, enzymes of the noradrenaline biosynthesis pathway, indicates that different genes contributing to the noradrenergic transmitter phenotype are regulated as a synexpression group. This conclusion is supported by the demonstration of bone morphogenetic protein (BMP) growth factors and Phox2 transcription factors being necessary for the expression of both tyrosine hydroxylase and dopamine beta-hydroxylase in differentiating sympathetic neurons. The close similarity in the expression patterns of the relevant genes as well as in the function of BMPs and Phox2s between avian and mammalian embryos strongly suggests that noradrenergic induction occurs along a conserved signalling pathway in these vertebrate classes.

  • References42
  • Citations10

References

  • References42
  • Citations10

Citations

Mentioned in this Paper

Vertebrates
Biochemical Pathway
Enzymes, antithrombotic
Sympathetic Nervous System
Neurons
Norepinephrine, (+, -)-Isomer
Embryonic Development
Bone Morphogenetic Proteins
Cell Differentiation Process
Dopamine-beta-monooxygenase

About this Paper

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