Oct 1, 1977

Evidence for an immunoglobulin-dependent antigen-specific helper T cell

Proceedings of the National Academy of Sciences of the United States of America
C A JanewayH Wigzell


Evidence from various systems suggests that thymus-derived lymphocytes can affect the quality of antibody responses by recognizing various portions of the immunoglobulin receptor of bone-marrow-derived thymus-independent lymphocytes. A model for this process is proposed involving two antigen-specific mature T helper cells, one of which also is specific for immunoglobulin determinants. These two cells act synergistically. Evidence from adoptive secondary antibody responses demonstrates that both cells are antigen-specific T cells and that the immunoglobulin-recognizing T helper cell is absent from experimentally agammaglobulinemic mice. This cell is termed an "immunoglobulin-dependent T cell" because its activation requires the presence of immunoglobulin.

  • References13
  • Citations70


  • References13
  • Citations70


Mentioned in this Paper

Mice, Inbred CBA
Immunofluorescence Assay
Immunoglobulin Activity
Mice, Inbred BALB C
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Neoplasm of Uncertain or Unknown Behavior of Thymus
Antigenic Specificity
Disease of Thymus Gland

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