Abstract
Malnutrition in haemodialysis (HD) patients has been referred to underdialysis with low protein intake, and to acidosis. However, the separate effects of underdialysis and acidosis on nutrition have not been clearly demonstrated. To evaluate the role of the dialysis dose and of metabolic acidosis on nutrition, we measured the predialysis serum HCO3, pH, serum albumin, PCRn, Kt/V, and BMI in 81 uraemic patients on maintenance bicarbonate HD for 93+/-80 months. Patients with chronic liver diseases, malignancies, and cachexia were excluded. Mean age was 59+/-17 years, Kt/V was 1.29+/-0.21, PCRn 1.06+/-0.22 g/kg/day, serum albumin 4.07+/-0.28 g/dl, BMI 23+/-4 kg/m2, HCO3 21.1+/-1.9 mmol/l, pH 7.36+/-0.04. Serum albumin showed a significant direct correlation with: PCRn (P=0.001), HCO3 (P=0.001), pH (P=0.002), but no correlation with Kt/V and BMI. Serum HCO3 correlated inversely with PCRn (P=0.027). Multiple regression analysis confirmed the significant role of serum bicarbonate and age, but not of Kt/V, on serum albumin concentrations. The role of PCRn appeared to be marginal compared to serum bicarbonate in determining serum albumin levels. Dividing patients into two groups, serum albumin was 3.96+/-0.22 g/dl with HCO3 < or = 20 m...Continue Reading
Citations
Jul 23, 2003·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Debra BlairStephen J Sweet
Jan 14, 2000·Kidney International. Supplement·J D LoudenT H Goodship
Nov 13, 2002·Kidney International·Trinh B PiferEric W Young
Feb 12, 2004·Kidney International. Supplement·Rajnish MehrotraMarsha Wolfson
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·N Cano
Dec 21, 2010·Seminars in Dialysis·Rhonda S King, Joel D Glickman
Oct 13, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Shing-Shing YehMichael W Schuster
Jan 22, 2005·Seminars in Dialysis·Kamyar Kalantar-ZadehJoel D Kopple
Oct 6, 2004·Seminars in Dialysis·Cheuk-Chun Szeto, Kai-Ming Chow
Nov 26, 2005·American Journal of Surgery·Elizabeth FitzSullivanMatthew J Martin
Apr 8, 2015·Seminars in Dialysis·Jagannath H Saikumar, Csaba P Kovesdy
Oct 12, 2017·Nutrients·Irene CapizziGiorgina Barbara Piccoli
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A Grzegorzewska
Oct 21, 2016·Pediatric Emergency Care·Naveen PoonaiRodrick Lim
Aug 10, 2005·Blood Purification·Ezio MovilliGiovanni Cancarini
Apr 16, 2002·Seminars in Dialysis·Marsha Wolfson
Jul 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G ToigoC Wanner
Oct 17, 2002·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Cathy VeroveRaymond Azar
Jun 19, 2021·Seminars in Nephrology·Eduardo A OliveiraRobert H Mak
Feb 17, 2009·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Ezio MovilliGiovanni C Cancarini
Jul 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation