Evidence for an inhibitory action of methyldopa on spinal sympathetic reflexes

European Journal of Pharmacology
T Baum, A T Shropshire


The antihypertensive activity of methyldopa is mediated primarily by effects on the central nervous system. A number of centrally acting hypotensive substances has recently been shown to depress spinal pathways and reflexes as well as inhibiting supraspinal areas. The present series of experiments evaluated the potential influence of methyldopa on spinal mechanisms. Stimulation of an intercostal nerve evoked a two-component response (early and late) in the splanchnic nerve of anesthetized cats. The "late" phase involves supraspinal neurons, whereas, the "early" component involves only spinal pathways. The i.v. administration of 100 mg/kg of methyldopa reduced systemic blood pressure and both components of the evoked potential progressively. These experiments indicate that methyldopa exerts an effect of spinal sympathetic mechanisms which may contribute to the antihypertensive response to the compound.


May 1, 1976·European Journal of Pharmacology·M F LokhandwalaB S Jandhyala
Jul 15, 1977·European Journal of Pharmacology·T Baum, A T Shropshire
Jun 1, 1975·European Journal of Pharmacology·M F LokhandwalaB S Jandhyala
Sep 8, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A Heise, G Kroneberg
Mar 1, 1973·European Journal of Pharmacology·M D DayR L Whiting
May 1, 1970·European Journal of Pharmacology·H KluppH Teichmann
Jun 1, 1968·The Journal of Pharmacy and Pharmacology·M Henning, P A van Zwieten
Jan 1, 1974·European Journal of Pharmacology·M J AntonaccioR Burrell
Oct 1, 1973·European Journal of Pharmacology·J N SinhaH Schmitt
Feb 1, 1973·British Journal of Pharmacology·L Finch, G Haeusler
Jul 1, 1966·Canadian Journal of Physiology and Pharmacology·B P JajuK P Bhargava

Related Concepts

Diastolic Blood Pressure
Felis catus
Depression, Chemical
Electric Stimulation Technique
Potentials, Event-Related
Pulse Rate
Reflex Action
Spinal Nerve Structure

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