PMID: 6407014Jun 1, 1983Paper

Evidence for an interleukin-independent pathway for human lymphocyte activation

Proceedings of the National Academy of Sciences of the United States of America
G KoretzkyP C Nowell

Abstract

Though lectin mitogen stimulation of T-cell proliferation is an interleukin 1- (IL 1), interleukin 2- (IL 2) dependent process, the calcium ionophore A23187 may be able to initiate T-lymphocyte proliferation by an additional pathway. That the action of A23187 is IL 1 independent was demonstrated by its ability to stimulate monocyte-depleted cells without the addition of exogenous IL 1. The IL 2 independence of A23187 was indicated by (i) the inability of exogenous IL 2 to augment A23187-induced proliferation and (ii) the inability of the monoclonal antibody anti-Tac (with specificity for the human IL 2 receptor) to inhibit proliferation mediated by A23187. By contrast, in cultures stimulated with the lectin mitogen phytohemagglutinin, additional IL 2 considerably increased proliferation, whereas anti-Tac routinely caused 60-90% inhibition. Although the ionophore caused some IL 2 production and resulted in IL 2 receptor expression, quantitative studies showed that our results could not be explained by excessive amounts of endogenous IL 2 interfering with the blocking action of the antibody. Therefore, these data suggest that the action of A23187 as a human lymphocyte mitogen may be the result of at least two pathways--one depend...Continue Reading

References

Jul 14, 1977·Nature·S Gillis, K A Smith
Feb 28, 1977·Biochimica Et Biophysica Acta·P JensenP Nowell
Jan 1, 1974·Biochemical and Biophysical Research Communications·G A Blondin
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J R LuckasenJ H Kersey
Jul 1, 1972·The Journal of Experimental Medicine·I GeryB H Waksman
Apr 1, 1981·Biochemical Pharmacology·Y MoritaR P Siraganian
Sep 1, 1982·The Journal of Immunology : Official Journal of the American Association of Immunologists·S C MeuerE L Reinherz
Jun 1, 1980·The Journal of Experimental Medicine·K A SmithM F Favata
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Gillis, S B Mizel
Nov 1, 1981·The Journal of Experimental Medicine·R J RobbK A Smith

❮ Previous
Next ❯

Citations

Jan 1, 1987·Cancer Metastasis Reviews·J F WhitfieldP R Walker
Mar 1, 1985·Journal of Clinical Immunology·H Tsuda, K Takatsuki
Jan 1, 1986·Immunologic Research·J S Goodwin
Jun 19, 1998·Biochimica Et Biophysica Acta·P Sanderson, P C Calder
Sep 3, 2004·Nature Reviews. Immunology·Thomas R Malek, Allison L Bayer
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M J WeissE L Reinherz
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L KaczmarekR Baserga
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R PahwaR A Good
Mar 1, 1990·Scandinavian Journal of Immunology·C S Larsen
Mar 1, 1984·Experimental Cell Research·R Baserga
Jun 1, 1986·Cellular Immunology·W HolterW Knapp
Oct 15, 1990·Cellular Immunology·R A FranklinK W Kelley
Dec 1, 1985·Scandinavian Journal of Immunology·H C CleversR E Ballieux
Sep 1, 1989·Scandinavian Journal of Immunology·C S Larsen, N O Christiansen
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min ShiLeslie J Berg
Oct 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arthur Weiss
Jan 1, 1988·Immunopharmacology and Immunotoxicology·R M Schultz, M G Altom
Jun 1, 1990·Kidney International·M KlingerS G Massry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.