Evidence for antifibrotic incretin-independent effects of the DPP-4 inhibitor linagliptin

Kidney International
Michael Zeisberg, Elisabeth M Zeisberg

Abstract

Among gliptins, linagliptin is unique, because decreased glomerular filtration rate does not require dose reduction. Linagliptin was originally developed to lower blood glucose by inhibiting dipeptidyl peptidase-4 (DPP-4). However, DPP-4 has numerous additional substrates, and thus gliptins possess a vast range of additional off-target effects. Shi et al. report that linagliptin directly targets interaction of DPP-4 with integrin β1, preventing endothelial-mesenchymal transition and ultimately renal fibrosis, providing additional rationale for use of linagliptin in diabetic nephropathy.

References

Jul 31, 2007·Nature Medicine·Elisabeth M ZeisbergRaghu Kalluri
Nov 7, 2008·Journal of the American Society of Nephrology : JASN·Elisabeth M ZeisbergRaghu Kalluri
Aug 3, 2012·Fibrogenesis & Tissue Repair·Ling XuDaisuke Koya
Apr 1, 2014·Fibrogenesis & Tissue Repair·Federica GenovesePeter Boor
Jul 10, 2014·Kidney International·Tetsuhiro TanakaMasaomi Nangaku
Oct 16, 2014·World Journal of Diabetes·Ioannis Ioannidis

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Citations

Feb 16, 2016·Fibrogenesis & Tissue Repair·Sen ShiKeizo Kanasaki
Apr 20, 2017·Journal of Molecular Endocrinology·Ahmed A Hasan, Berthold Hocher
Apr 15, 2018·Current Diabetes Reports·Scott C Thomson, Volker Vallon
Sep 5, 2017·Nature Reviews. Nephrology·Marcel H A MuskietDaniël H van Raalte
Oct 27, 2016·Plastic and Reconstructive Surgery·Michael S Hu, Michael T Longaker
May 24, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jian XuHui Kong
Aug 31, 2017·The New England Journal of Medicine·Johannes F E MannUNKNOWN LEADER Steering Committee and Investigators
Jan 30, 2021·Kidney International·Masaomi Nangaku, Christoph Wanner
Jul 30, 2020·Canadian Journal of Physiology and Pharmacology·Maaly Abd ElmaaboudShahinaz Shalaby
Apr 23, 2021·Advanced Drug Delivery Reviews·Cláudia AzevedoBruno Sarmento

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