Evidence for arginine vasopressin as the primary activator of the HPA axis during adjuvant-induced arthritis

British Journal of Pharmacology
H S ChowdreyS L Lightman

Abstract

1. Adjuvant-induced arthritis (AA) is an experimental inflammation of the joints that results in chronic activation of the hypothalamo-pituitary-adrenal (HPA) axis. 2. In this study the role of hypothalamic corticotrophin-releasing factor (CRF) and arginine vasopressin (AVP) in the regulation of the HPA axis in this condition both in Sprague-Dawley (SD), and Piebald-Viral-Glaxo (PVG) rats has been further characterized. 3. The increase in AVP peptide content of portal blood (as early as day 11), just prior to the onset of arthritis is confirmed and further increases, peaking at day 16 are shown, coincident with the progression of inflammation in the PVG rats. 4. The increase in AVP is associated with a significant increase in the expression of AVP but not CRF mRNAs in the medial parvocellular division of the hypothalamic paraventricular nucleus (PVN) of arthritic SD rats. 5. In the presence of maximal inflammation of SD rats there was a significant decrease in the maximum binding of [125I]-Tyr-oCRF to anterior pituitary membranes, whereas AVP receptor concentration in anterior pituitary membranes from both PVG and SD rats showed a significant increase with respect to controls. 6. The basal adrenocorticotrophin (ACTH) secretion ...Continue Reading

References

Mar 29, 1979·Nature·G Gillies, P Lowry
Sep 1, 1992·The Journal of Endocrinology·M S Harbuz, S L Lightman
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M O FăgăraşanJ Axelrod
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L Lightman, W S Young
Sep 1, 1989·The Journal of Endocrinology·M S Harbuz, S L Lightman
Jan 1, 1986·Annual Review of Physiology·C L Rivier, P M Plotsky
Feb 1, 1985·Endocrinology·T D WilliamsS L Lightman
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R Ivell, D Richter
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P E SawchenkoW W Vale

❮ Previous
Next ❯

Citations

Feb 1, 1997·Journal of Neuroimmunology·K KaralisJ A Majzoub
Mar 16, 2000·Journal of Neuroendocrinology·H KinoshitaM S Harbuz
Jan 10, 2002·Journal of Neurotrauma·P L GrundyP M Sharples
Sep 6, 2011·Rheumatology·Simon C BiddieStafford L Lightman
Jun 18, 1998·Annals of the New York Academy of Sciences·N ShanksS L Lightman
Feb 28, 2002·Annual Review of Immunology·Jeanette I WebsterEsther M Sternberg
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·N ShanksS L Lightman
Aug 15, 2013·The Journal of Endocrinology·Anna FodorDóra Zelena
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Signe F BomholtRuth E Blackburn-Munro
Apr 6, 2002·Archives of Physiology and Biochemistry·S L LightmanC D Ingram
Feb 2, 2010·Journal of Pharmacological and Toxicological Methods·Jessica M McKlveenMichael E Rhodes
Jun 10, 2003·Annals of the New York Academy of Sciences·Michael S HarbuzDavid S Jessop
Feb 25, 2009·Annals of the New York Academy of Sciences·Istvan BercziKalman Kovacs
Jul 8, 2008·Journal of Neuroendocrinology·S L Lightman
Jul 21, 2006·Annals of the New York Academy of Sciences·M S HarbuzD S Jessop
Jan 6, 2009·Annals of the New York Academy of Sciences·Jun ChenGreti Aguilera
May 12, 2005·Brain Research·Signe F BomholtGordon Blackburn-Munro
Jun 9, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Oliver G BoschThomas C Wetter
Jul 25, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·M S Harbuz
Nov 17, 2011·Molecular and Cellular Endocrinology·Ferenc A Antoni
Apr 15, 2000·Frontiers in Neuroendocrinology·F A Antoni
Aug 14, 1997·Annals of the New York Academy of Sciences·M S HarbuzD S Jessop
Jun 10, 2003·Annals of the New York Academy of Sciences·Inge HuitingaDick F Swaab
May 26, 2016·American Journal of Physiology. Endocrinology and Metabolism·R RaoI P Androulakis

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