Evidence for association between familial bipolar risk and ventral striatal volume

Journal of Affective Disorders
Thomas M Lancaster

Abstract

Recent genome-wide association studies (GWAS) of striatal volumes and bipolar disorder (BD) indicate these traits are heritable and share common genetic architecture, however little independent work has been conducted to help establish this relationship. Subcortical volumes (mm3) of young, healthy offspring of BD (N= 32) and major depressive disorder (MDD) patients (N= 158) were compared to larger healthy control sample (NRANGE= 925-1052) adjusting for potential confounds, using data from the latest release (S1200) of the Human Connectome Project. Based on recent GWAS findings, it was hypothesised that the accumbens and caudate would be smaller in offspring of BD, but not MDD patients. After multiple comparison correction, there was a regional and BD specific relationship in the direction expected (Accumbens: F2,1067= 6.244, PFDR-CORRECTED= 0.014). In line with recent GWAS, there was evidence supporting the hypothesis that reduced striatal volume may be part of the genetic risk for BD, but not MDD. It cannot be concluded whether this association was specific to BD or consistent with a broader psychosis phenotype, due to a small sample size for offspring of schizophrenia patients. Furthermore, one cannot rule out potential share...Continue Reading

Citations

Sep 12, 2021·NeuroImage·Jennifer Stine ElamDavid C Van Essen

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