Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Robert GoertschesManuel Comabella

Abstract

A recent association study has provided evidence that chromosome 10q22.1 may contain candidate genes for multiple sclerosis (MS). We analysed two intronic and a non-synonymous single nucleotide polymorphism (SNP) of the C10orf27 gene in 571 patients with MS (relapsing remitting and primary progressive) and healthy controls. Adjusted comparisons revealed significant association with disease susceptibility for one intronic SNP in RRMS individuals and the amino acid modifying SNP for PPMS cases; the latter may also contribute to faster disease progression. Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis.

References

Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S E BaranziniJ R Oksenberg
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Oct 25, 2003·Journal of Neuroimmunology·Robert GoertschesUNKNOWN Spanish MS Genetics Group
Jan 30, 2004·Lancet Neurology·David A DymentA Dessa Sadovnick
May 26, 2005·Journal of Neuroimmunology·Robert GoertschesXavier Montalban

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Citations

May 23, 2008·Genes and Immunity·G CappellanoU Dianzani
Sep 14, 2013·Journal of Proteomics·Gabriel EspinosaIñaki Alvarez
Oct 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Montse Camiña-TatoManuel Comabella
May 7, 2009·Current Opinion in Neurology

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