Evidence for association of the myo-inositol monophosphatase 2 (IMPA2) gene with schizophrenia in Japanese samples

Molecular Psychiatry
T YoshikawaS D Detera-Wadleigh

Abstract

In our search for candidate genes for affective disorder on the short arm of chromosome 18, we cloned IMPA2, a previously unreported myo-inositol monophosphatase gene, that maps to 18p11.2. We determined its genomic structure and detected three new single nucleotide polymorphisms (SNPs). In the present study, we screened the gene further to search for additional polymorphisms in Japanese samples and identified seven other SNPs, including a novel missense mutation. These polymorphisms clustered into three regions of the gene. Three relatively informative SNPs, 58G>A, IVS1--15G>A and 800C>T from clusters 1, 2 and 3, respectively, were selected for association tests using a case-control design. The Japanese cohort included 302 schizophrenics, 205 patients with affective disorder and 308 controls. Genotyping was done either by melting curve analysis on the LightCycler or by sequencing. All three SNPs showed significant genotypic association (nominal P = 0.031--0.0001) with schizophrenia, but not with affective disorder. These findings increase the relevance of 18p11.2 to schizophrenia susceptibility because GNAL, which has been shown previously to be implicated in schizophrenia in an independent study, is in close physical proximit...Continue Reading

References

Sep 1, 1988·Gynecologic Oncology·C J Cohen
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J PollackH B Broughton
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·W H BerrettiniE S Gershon
Aug 1, 1996·Brain Research. Brain Research Reviews·J R Atack
Apr 18, 1997·American Journal of Medical Genetics·T YoshikawaS D Detera-Wadleigh
Oct 20, 1998·Biological Psychiatry·H ShimonG Agam
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·S D Detera-WadleighE S Gershon
Oct 3, 1999·Schizophrenia Research·D B WildenauerS D Detera-Wadleigh
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·A CollinsN E Morton
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Ott
May 24, 2000·Molecular Psychiatry·T YoshikawaS D Detera-Wadleigh

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Citations

Jun 9, 2005·Molecular Psychiatry·E HattoriE S Gershon
Jul 27, 2005·Molecular Psychiatry·J P CorradiS T Furlong
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tetsuo OhnishiTakeo Yoshikawa
Jun 19, 2001·Annals of Medicine·S D Detera-Wadleigh
Feb 16, 2010·Neuroscience Research·Tetsuo OhnishiTakeo Yoshikawa
Nov 21, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Juan ZavalaMichael Escamilla
May 4, 2004·Biological Psychiatry·Pavla StopkovaHerbert M Lachman
Feb 13, 2002·American Journal of Medical Genetics·Tomoko ToyotaTakeo Yoshikawa
Oct 29, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Pavla StopkovaHerbert M Lachman
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Wade Berrettini
Mar 26, 2004·The Pharmacogenomics Journal·N NakataniT Yoshikawa
Aug 31, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·O MukherjeeS Jain
Aug 12, 2005·Psychiatric Genetics·Pavla StopkovaHerbert M Lachman
Apr 5, 2019·Journal of Atherosclerosis and Thrombosis·Akemi KakinoTatsuya Sawamura
May 23, 2009·Journal of Human Genetics·Joanne M A MeerabuxTakeo Yoshikawa
Jun 27, 2017·Pharmacological Reports : PR·Michal OrdakMagdalena Bujalska-Zadrozny
Oct 7, 2004·Archives of Biochemistry and Biophysics·Ratnam S SeelanRanga N Parthasarathy
Oct 27, 2004·Biochemical and Biophysical Research Communications·Ratnam S SeelanRanga N Parthasarathy

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