Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice

Arthritis and Rheumatism
K FujisawaK Nishioka

Abstract

To examine T cell clonotypes infiltrating into arthritic joints and to investigate whether human T cell leukemia virus type I (HTLV-I) env-pX gene products act as autoantigens in HTLV-I env-pX transgenic mice. Complementary DNA (cDNA) encoding the V-D-J (third complementarity-determining region [CDR3]) region of T cell receptor beta chain was amplified by Vbeta family polymerase chain reaction. T cell clonotypes were detected by a single-strand conformational polymorphism method, and sequence analysis of the CDR3 region was performed. Distinct oligoclonal T cell expansion was observed in arthritic joints, and a conserved amino acid motif in the CDR3 region was found in T cells infiltrating joints. Moreover, several intraarticular T cells recognized HTLV-I Env and Tax proteins. Our results suggest that HTLV-I Env and Tax proteins act as autoantigens that are recognized by autoreactive T cells in inflamed arthritic lesions in the HTLV-I env-pX transgenic mouse. Thus, some T cells infiltrating the joint recognize Env or Tax protein. These cells may trigger chronic arthritis in HTLV-I env-pX transgenic mice.

References

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Citations

Dec 21, 2000·Current Rheumatology Reports·D Zucker-Franklin
Jun 6, 2003·Best Practice & Research. Clinical Rheumatology·Kayo Masuko-HongoKusuki Nishioka
Jul 5, 2005·Expert Opinion on Investigational Drugs·T PapS Gay
Jan 11, 2002·Experimental and Molecular Pathology·Toshiaki SugayaTakashi Yoshiki
Oct 2, 2004·Clinical Rheumatology·Tomohiro KatoKusuki Nishioka
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nino MancaCorrado Angelini

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