Evidence for avian and human host cell factors that affect the activity of influenza virus polymerase.

Journal of Virology
Olivier MoncorgéW S Barclay

Abstract

Typical avian influenza A viruses do not replicate efficiently in humans. The molecular basis of host range restriction and adaptation of avian influenza A viruses to a new host species is still not completely understood. Genetic determinants of host range adaptation have been found on the polymerase complex (PB1, PB2, and PA) as well as on the nucleoprotein (NP). These four viral proteins constitute the minimal set for transcription and replication of influenza viral RNA. It is widely documented that in human cells, avian-derived influenza A viral polymerase is poorly active, but despite extensive study, the reason for this blockade is not known. We monitored the activity of influenza A viral polymerases in heterokaryons formed between avian (DF1) and human (293T) cells. We have discovered that a positive factor present in avian cells enhances the activity of the avian influenza virus polymerase. We found no evidence for the existence of an inhibitory factor for avian virus polymerase in human cells, and we suggest, instead, that the restriction of avian influenza virus polymerases in human cells is the consequence of the absence or the low expression of a compatible positive cofactor. Finally, our results strongly suggest tha...Continue Reading

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Citations

Jun 15, 2012·Journal of Virology·Dorothée MoisyJean-Luc Jestin
Oct 19, 2012·Journal of Virology·Olivier MoncorgéWendy S Barclay
Jan 6, 2011·The Journal of Clinical Investigation·Donna M Tscherne, Adolfo García-Sastre
May 23, 2012·PloS One·Caroline ChuYoshihiro Kawaoka
Mar 29, 2014·Veterinary Microbiology·Celia Abolnik
Sep 26, 2015·Annual Review of Genetics·Florian DouamAlexander Ploss
Sep 27, 2013·Influenza and Other Respiratory Viruses·Aurora Romero-Tejeda, Ilaria Capua
Apr 8, 2011·The Journal of General Virology·Ágnes FoegleinPaul Digard
Mar 4, 2014·The Journal of General Virology·Anna V CauldwellWendy S Barclay
Nov 29, 2014·Future Virology·Thomas M Stubbs, Aartjan Jw Te Velthuis
Sep 30, 2014·Trends in Microbiology·Tokiko WatanabeYoshihiro Kawaoka
Sep 13, 2014·Current Opinion in Virology·Kazuhiro Ishibashi, Masayuki Ishikawa
Oct 27, 2016·Viruses·Alina Rudnicka, Yohei Yamauchi
Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Jun 6, 2014·Journal of Virology·Volker Czudai-MatwichHans-Dieter Klenk
Jan 27, 2017·Journal of Virology·Benjamin E NilssonErvin Fodor

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