PMID: 9548181Apr 21, 1998Paper

Evidence for basic fibroblast growth factor as a crucial angiogenic growth factor, released from human trophoblasts during early gestation

Placenta
Y HamaiY Taketani

Abstract

The objective of this study was to clarify the possible angiogenesis-promoting factors from human trophoblasts in early stage gestation. The existence of angiogenic growth factors such as basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in the condition medium from human villous trophoblasts was determined. Biological activity of angiogenic growth factors released by trophoblasts was examined using vascular endothelial cell lines. The condition medium from trophoblasts enhanced the growth of endothelial cells. Although cultured trophoblasts exhibited immunoreactive products for both bFGF and VEGF in the cytoplasm, only bFGF was detected in the condition medium by ELISA. The growth-enhancing activity of the condition medium was eliminated completely by the addition of anti-bFGF antibody but not with anti-VEGF antibody. Thus, trophoblastic cells seem to play an important role in extensive angiogenesis occurring in early gestation, mainly by releasing bFGF but not VEGF.

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Citations

Jul 10, 2007·Journal of Assisted Reproduction and Genetics·Donald S TorryRonald J Torry
Sep 1, 2005·Environmental Toxicology and Pharmacology·Sohail Ejaz, Chae Woong Lim
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marek ZygmuntOlin D Liang
Mar 27, 2004·Reproductive Biology and Endocrinology : RB&E·Rama Soundararajan, A Jagannadha Rao
Apr 24, 2010·Diagnostic Pathology·Figen BarutSukru Oguz Ozdamar
Jan 10, 2012·Gynecologic and Obstetric Investigation·Aykut BarutBanu Dogan Gun
Feb 14, 2006·The Journal of Dermatology·Müzeyyen GönülMurat Demiriz
Mar 3, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D SchlembachU Lang
Mar 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eyal Y AntebySimcha Yagel
Jan 21, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael G Elliot, Bernard J Crespi

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