Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.

The American Journal of Pathology
Sylvia PappMichal Opas

Abstract

While calreticulin has been shown to be critical for cardiac development, its role in cardiac pathology is unclear. Previous studies have shown the detrimental effects on the heart of sustained germline calreticulin overexpression, yet without calreticulin, the heart does not develop normally. Thus, carefully balanced calreticulin levels are required for the heart to develop and to function properly into adulthood. But what happens to calreticulin levels, and how is this regulated, during cardiac hypertrophy, during which the fetal gene program is reactivated, at least partially? Our working hypothesis was that c-Src, a kinase whose activity we previously found to be correlated with calreticulin expression, was involved with calreticulin in regulating the response to hypertrophic signals. Thus, we subjected adult mice to transverse aortic constriction to induce left ventricular hypertrophy. We found that aortic constriction caused calreticulin levels to increase, whereas those of c-Src fell with longer constriction time. We also examined the ability of embryonic stem cell-derived cardiomyocytes to respond to soluble hypertrophic agonists. Endothelin-1 treatment caused a significantly greater cell area increase of calreticulin-n...Continue Reading

References

May 12, 1995·The Journal of Biological Chemistry·W H Herman, M S Simonson
Jan 5, 1996·The Journal of Biological Chemistry·M S SimonsonW H Herman
Feb 14, 1997·The Journal of Biological Chemistry·D KuppuswamyG Cooper
Jan 1, 1997·The American Journal of Physiology·H TsutsuiA Takeshita
Jan 22, 1998·Current Opinion in Structural Biology·F Sicheri, J Kuriyan
Dec 18, 1998·The Journal of Biological Chemistry·B KovacicD G Gardner
Mar 23, 1999·The Journal of Cell Biology·N MesaeliM Michalak
Oct 21, 1999·The New England Journal of Medicine·J J Hunter, K R Chien
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·T TaigenJ D Molkentin
Aug 26, 2000·The Journal of Biological Chemistry·M LaserD Kuppuswamy
May 26, 2001·The Journal of Clinical Investigation·K NakamuraM Michalak
Jul 10, 2002·The Journal of Cell Biology·Jian LiMarisa E Jaconi
May 29, 2003·The Journal of Biological Chemistry·Liming Shu, James A Shayman
Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Peter H Sugden
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jürgen Borlak, Thomas Thum
Nov 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cesare CuspidiAlberto Zanchetti
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin
Mar 29, 2007·The Journal of Biological Chemistry·Sylvia PappMichal Opas
May 8, 2007·Molecular Genetics and Metabolism·Kiyoko HattoriFumio Endo
Feb 8, 2008·Experimental Cell Research·Sylvia PappMichal Opas
Jan 13, 2009·The Biochemical Journal·Marek MichalakMichal Opas

❮ Previous
Next ❯

Citations

Feb 4, 2014·Bioinformatics·Klaus JungTim Beißbarth
Feb 14, 2012·Journal of Molecular and Cellular Cardiology·Peter J BelmontChristopher C Glembotski
Sep 17, 2013·Journal of Cellular Physiology·Nicolas BousetteAnthony O Gramolini
Feb 20, 2015·International Journal of Molecular Medicine·Chuntao WuYongjun Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.