Evidence for chaotic behavior in driven ventricles

Biophysical Journal
G V SavinoM E Valentinuzzi

Abstract

Toad ventricles were externally driven by periodic pulses while monophasic action potential (MAP) signals were recorded in seven excised and seven in situ ventricles. As the frequency was slowly increased in steps, the stimulated tissue displayed several dynamic characteristics. Hierarchies of periodic behavior, like phase-locking and period-doubling sequences leading to chaos, were observed. Results showed that subharmonic bifurcations (order one and two) and chaotic-like behavior may systematically occur in the MAP signal within a definite frequency interval in the 1:1 phase locking regime. The chaotic, or more cautiously expressed, chaotic-like behavior is characterized by the power spectrum, the autocorrelation function, the Poincaré map, and the reconstructed 2-D phase portrait. It is concluded that (a) bifurcations of order one and two and the characteristic irregular behavior are evidences of local universal chaotic dynamics in cardiac tissue; (b) there are no qualitative differences in the dynamics of the in situ and excised ventricles; and (c) fibrillation seems to be related to chaotic behavior, but whether they are similar or equivalent phenomena still remains to be seen.

Citations

Jan 1, 1992·Biological cybernetics·F Ravelli, R Antolini
Mar 1, 1995·Trends in Cardiovascular Medicine·A GarfinkelM L Spano
Mar 10, 1999·Progress in Biophysics and Molecular Biology·M J Lab
Jun 5, 2003·Chaos·Humberto ArceMichael R. Guevara
Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·P S ChenH S Karagueuzian
May 1, 1994·Journal of Cardiovascular Electrophysiology·R L Verrier, B D Nearing
Aug 2, 2000·Journal of Cardiovascular Electrophysiology·R A OliverD J Gauthier
Jan 15, 1997·The Journal of Clinical Investigation·A GarfinkelJ N Weiss
Aug 21, 2007·Journal of Theoretical Biology·Alejandro LópezMichael R Guevara
Mar 6, 2007·Journal of Theoretical Biology·H Croisier, P C Dauby
Sep 30, 2010·IEEE Pulse·M E ValentinuzziR Spelzini
Oct 7, 1990·Journal of Theoretical Biology·T J Lewis, M R Guevara
Feb 3, 2004·Physical Review Letters·Rodrigo Laje, Gabriel B Mindlin
Jun 4, 2004·Journal of Cardiovascular Electrophysiology·Soma S KalbDaniel J Gauthier
Jan 1, 1990·Annals of the New York Academy of Sciences·A VinetJ Jalife
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hortensia GonzálezMichael R Guevara
Jan 16, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Noëlle FiammaThomas Similowski
Aug 1, 1992·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·G C Fisher
Apr 20, 2004·Journal of Cardiovascular Electrophysiology·Isabelle BanvilleRichard A Gray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.