PMID: 9003071Feb 1, 1997Paper

Evidence for circadian variations of thyroid hormone concentrations and type II 5'-iodothyronine deiodinase activity in the rat central nervous system

Journal of Neurochemistry
A Campos-BarrosA Baumgartner

Abstract

The 24-h patterns of tissue thyroid hormone concentrations and type II 5'- and type III 5-iodothyronine deiodinase (5'D-II and 5D-III, respectively) activities were determined at 4-h intervals in different brain regions of male euthyroid rats entrained to a regular 12-h light/12-h dark cycle (lights on at 6:00 a.m.). Activity of 5'D-II, which catalyzes the intracellular conversion of thyroxine (T4) to 3,3',5-triiodo-L-thyronine (T3) in the CNS, and the tissue concentrations of both T4 and T3 exhibited significant daily variations in all brain regions examined. Periodic regression analysis revealed significant circadian rhythms with amplitudes ranging from 9 to 23% (for T3) and from 15 to 40% (for T4 and 5'D-II) of the daily mean value. 5'D-II activity showed a marked nocturnal increase (1.3-2.1-fold vs. daytime basal value), with a maximum at the end of the dark period and a minimum between noon and 4:00 p.m. 5D-III did not exhibit circadian patterns of variation in any of the brain tissues investigated. Our results disclose circadian rhythms of 5'D-II activity and thyroid hormone concentrations in discrete brain regions of rats entrained to a regular 12:12-h light-dark cycle and reveal that, in the rat CNS, T3 biosynthesis is ...Continue Reading

Citations

Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Ronald M Lechan, Csaba Fekete
Jul 5, 2012·Endocrinology·Ricardo H Costa-e-Sousa, Anthony N Hollenberg
Sep 22, 2005·Endocrine Reviews·J KöhrleJ E Dumont
Jan 5, 2002·Molecular Endocrinology·Frédéric FlamantJacques Samarut
Jun 11, 2009·Thyroid : Official Journal of the American Thyroid Association·Nagaoki ToyodaMitsushige Nishikawa
Sep 26, 2008·Endocrine Reviews·Balázs GerebenAntonio C Bianco
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Françoise CourtinMichel Pierre
Nov 8, 2017·Chronobiology International·Rodrigo A Peliciari-GarciaMaria Tereza Nunes
Oct 8, 2013·General and Comparative Endocrinology·R A JonesD S Mackenzie
May 11, 1999·Brain Research. Brain Research Protocols·G PinnaA Baumgartner
Jul 3, 2021·Nutrition and Metabolic Insights·Husein MohammedAregash Samuel
Sep 21, 2021·Frontiers in Endocrinology·Birgitte GeorgJens Hannibal
Jun 15, 2011·Molecular and Cellular Endocrinology·I SchmutzJ A Ripperger

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