PMID: 9525676Apr 3, 1998Paper

Evidence for cooperation between murine leukemia virus Env molecules in mixed oligomers

Journal of Virology
A ReinR W Compans

Abstract

A retroviral Env molecule consists of a surface glycoprotein (SU) complexed with a transmembrane protein (TM). In turn, these complexes are grouped into oligomers on the surfaces of the cell and of the virion. In the case of murine leukemia viruses (MuLVs), the SU moieties are polymorphic, with SU proteins of different viral isolates directed towards different cell surface receptors. During maturation of the released virus particle, the 16 C-terminal residues of TM (the R peptide or p2E) are removed from the protein by the viral protease; this cleavage is believed to activate the membrane-fusing potential of MuLV Env. We have tested the possibility that different MuLV Env proteins in the same cell can interact with each other, both physically and functionally, in mixed oligomers. We found that coexpressed Env molecules can be precipitated out of cell lysates by antiserum which reacts with only one of them. Furthermore, they can evidently cooperate with each other: if one Env species lacks the R peptide, then it can apparently induce fusion if the SU protein of the other Env species encounters its cognate receptor on the surface of another cell. This functional interaction between different Env molecules has a number of implicat...Continue Reading

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Citations

Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ZhaoW F Anderson
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·K Salzwedel, E A Berger
Jul 20, 2007·Journal of Virology·Samuel L Murphy, Glen N Gaulton
Apr 11, 2006·The Journal of General Virology·M CarmoP E Cruz
Apr 4, 2021·Viruses·Alan Rein
Mar 29, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·T Zavorotinskaya, L M Albritton
Oct 31, 2007·Biotechnology and Bioengineering·Natalia Landázuri, Joseph M Le Doux

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