Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human erythroleukemic cells

Biochemical Pharmacology
Franck MorceauC Trentesaux

Abstract

Human erythroleukemic K 562 cells were induced to were induced to differentiate along the erythroid lineage by anthracycline antitumor drugs, such as aclacinomycin (ACLA) and doxorubicin (DOX). Subsequent stimulation of heme and globin synthesis led to a differential quantitative expression of hemoglobins. Gower 1 (epsilon2, zeta2) was the major type for ACLA and X (epsilon2, gamma2) for DOX. Although ACLA and DOX increased both the expression of gamma-globin and porphobilinogen deaminase mRNAs, striking differences were observed in the expression of erythropoietin receptor mRNAs and in erythroid transcription factors GATA-1 and NF-E2, known to play a key role in erythroid gene regulation. Indeed, ACLA induces an increase either in the binding capacity of GATA-1 and NF-E2 or in the accumulation of erythropoietin receptor, GATA-1 and NF-E2 transcripts. In contrast, their expression with DOX was not significantly modified compared to uninduced cells, except for a slight decrease in NF-E2 expression on day 3. In conclusion, these data show that: 1. increased expression of erythroid transcription factors and erythroid genes are associated only with ACLA treatment, and 2. although cytotoxicity of both ACLA and DOX is certainly depen...Continue Reading

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Citations

Nov 19, 2003·Biochemical and Biophysical Research Communications·Michael SchnekenburgerMarc Diederich
Mar 19, 2008·Biochemical Pharmacology·Malgorzata CzyzMalgorzata Sztiller-Sikorska
Feb 3, 2000·Free Radical Biology & Medicine·B ChénaisP Jeannesson
Mar 28, 2013·Endocrine-related Cancer·Meenu JainElectron Kebebew
Jun 19, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G Berkovitch-LuriaZ Malik
Jun 5, 2007·The International Journal of Biochemistry & Cell Biology·Mohammad Amin MoosaviAbbas Lotfi
Nov 22, 2007·Blood Cells, Molecules & Diseases·Hassana FathallahGeorge F Atweh
Sep 28, 2005·Biochemical Pharmacology·Malgorzata CzyzMarkus Düchler
Jan 22, 2005·Annals of the New York Academy of Sciences·Franck MorceauMarc Diederich
Jul 25, 2009·British Journal of Pharmacology·M Sztiller-SikorskaM Czyz
Apr 19, 2015·Biotechnology Advances·Franck MorceauMarc Diederich
May 16, 2000·Biochemical Pharmacology·N BianchiR Gambari

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