PMID: 7162360Dec 27, 1982

Evidence for dopaminergic modulation of pancreatic polypeptide secretion in man

Life Sciences
J R SowersI L Taylor

Abstract

This study examines the role of dopaminergic mechanisms in the regulation of human pancreatic polypeptide (hPP) secretion in 11 normal male volunteers. Administration of domperidone (20 mg iv), an extracerebral inhibitor of dopamine receptors, resulted in a hPP rise (p less than 0.05) within 10 min and a peak response (p less than 0.01) at 15 min after drug administration. Administration of the dopaminergic agonist, bromocriptine, 2.5 mg tid for 4 days eliminated hPP responses to isometric handgrip exercise in these 11 volunteers. These results suggest that dopaminergic mechanisms may exert a tonic inhibitory effect on hPP secretion in normal subjects.

References

May 1, 1979·The Journal of Pharmacy and Pharmacology·B CostallR J Naylor
Jun 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R W McCallumR A Sturdevant
Sep 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J R SowersN Meyer
Aug 1, 1976·Neuropharmacology·R Miller
Oct 1, 1980·The Journal of Clinical Endocrinology and Metabolism·L WhitfieldM S Golub
Jun 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G DelitalaG Lotti

Citations

Dec 15, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Marcus M UngerW H Oertel
Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Sep 19, 2017·Journal of Parkinson's Disease·Karoline KnudsenPer Borghammer
Aug 1, 1992·Gastroenterologia Japonica·Y NagahataY Saitoh

Related Concepts

Parlodel
Domperidone Maleate (1: 1)
Isometric Contraction
Pancreatic Prohormone
Dopamine Receptor
Dopamine Antagonists

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