Evidence for dopaminergic vasodilator innervation of the canine paw pad

British Journal of Pharmacology
C Bell, W J Lang

Abstract

1 In chloralose-anaesthetized dogs pretreated with guanethidine and pancuronium, electrical stimulation (0.2 to 5 Hz) of the peripheral end of the cut tibial nerve caused a frequency-dependent increase in femoral blood flow which was restricted to the paw pads. 2 This neurogenic vasodilatation was not attenuated by atropine, mepyramine plus burimamide, indomethacin or propranolol. It was, however, attenuated in a dose-dependent manner by intra-arterial administration of the dopamine receptor antagonist, ergometrine (0.05 to 0.5 mg). 3 The effect of ergometrine could not be explained by non-specific effects on axonal conduction or transmission or by vasospasm of the blood vessels of the paw-pads. 4 In dogs with intact tibial nerves, a pharmacologically similar dilator response localized to the paw-pads could be elicited by electrical stimulation of loci in the ipsilateral diencephalon and midbrain. This response was not due to inhibition of adrenergic vasomotor tone and was abolished by systemic ganglion blockade or by tibial nerve section as well as by femoral arterial administration of ergometrine. 5 It is suggested that the vasculature of the canine paw pads is innervated by a population of autonomic axons which utilize dopam...Continue Reading

References

Jul 1, 1978·Journal of Neurochemistry·C BellF Laska
Oct 1, 1978·British Journal of Pharmacology·C Bell, A Stubbs
Mar 1, 1975·Pharmacology, Biochemistry, and Behavior·B K EvansG Burnstock
Oct 1, 1975·British Journal of Pharmacology·C BellR Padanyi
Sep 16, 1973·Pflügers Archiv : European journal of physiology·B H Graham, F Lioy
May 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S L EngelB Rubin
Feb 1, 1970·The American Journal of Physiology·M J Brody, R A Shaffer
Oct 1, 1972·The American Journal of Physiology·T F Rolewicz, B G Zimmerman
Dec 1, 1972·The American Journal of Physiology·C H Baker
Nov 1, 1970·The American Journal of Physiology·D R BallardH E Mayer
Jan 1, 1968·The American Journal of Physiology·B G Zimmerman
Sep 1, 1957·British Medical Bulletin·S M HILTON, G P LEWIS
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Citations

Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·P Soares-da-Silva
Jan 1, 1989·Pharmacology & Therapeutics·C Bell
Mar 1, 1983·Journal of the Autonomic Nervous System·C Bell
Jan 1, 1992·Journal of the Autonomic Nervous System·M Kawarai, M C Koss
Nov 10, 1998·The Journal of Physiology·B G WallinM Elam
Aug 1, 1984·British Journal of Pharmacology·C Bell, A C Rome
May 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C Bell, E M McLachlan
Feb 1, 1981·Journal of Neurochemistry·C Bell, J S Gillespie
Sep 1, 1982·Journal of Autonomic Pharmacology·M F Lokhandwala, R J Barrett
Nov 1, 1986·British Journal of Clinical Pharmacology·A HughesP Sever

Related Concepts

Metazoa
Atropine Sulfate Anhydrous
Central Nervous System
Canis familiaris
Intropin
Electric Stimulation Technique
Foot
Antihistamines, Classical
Perineurium
Regional Blood Flow

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