Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

Science
Jean-Pierre VartanianSimon Wain-Hobson

Abstract

Cytidine deaminases of the APOBEC3 family all have specificity for single-stranded DNA, which may become exposed during replication or transcription of double-stranded DNA. Three human APOBEC3A (hA3A), hA3B, and hA3H genes are expressed in keratinocytes and skin, leading us to determine whether genetic editing of human papillomavirus (HPV) DNA occurred. In a study of HPV1a plantar warts and HPV16 precancerous cervical biopsies, hyperedited HPV1a and HPV16 genomes were found. Strictly analogous results were obtained from transfection experiments with HPV plasmid DNA and the three nuclear localized enzymes: hA3A, hA3C, and hA3H. Thus, stochastic or transient overexpression of APOBEC3 genes may expose the genome to a broad spectrum of mutations that could influence the development of tumors.

References

May 17, 2003·Science·Denise LecossierAllan J Hance
Jun 18, 2003·Cell·Reuben S HarrisMichael H Malim
Jul 16, 2003·Cell·Roberto MarianiNathaniel R Landau
May 4, 2004·Nucleic Acids Research·Rodolphe SuspèneJean-Pierre Vartanian
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Aug 7, 2004·Current Biology : CB·Kate N BishopMichael H Malim
Oct 22, 2004·Molecular Biology and Evolution·Silvestro G ConticelloMichael S Neuberger
Dec 18, 2004·The Journal of General Virology·Rodolphe SuspèneJean-Pierre Vartanian
Mar 5, 2005·Molecular Biology and Evolution·Matthew SpencerAndrew J Roger
Apr 16, 2005·The Lancet Oncology·Vincent CoglianoUNKNOWN WHO International Agency for Research on Cancer
May 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Rodolphe SuspèneJean-Pierre Vartanian
Mar 11, 2006·The Journal of Investigative Dermatology·Nishit R TrivediDiane M Thiboutot
May 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hal P BogerdBryan R Cullen
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Jan 30, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marc Arbyn, Joakim Dillner
Mar 3, 2007·Annual Review of Biochemistry·Javier M Di Noia, Michael S Neuberger
Mar 9, 2007·Nature·Christopher GreenmanMichael R Stratton
Apr 19, 2007·Nucleic Acids Research·Masanobu KinomotoKenzo Tokunaga
Jun 15, 2007·Advances in Immunology·Myron F GoodmanFloyd E Romesberg
Jun 15, 2007·Advances in Immunology·Il-mi OkazakiTasuku Honjo

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Citations

Mar 8, 2011·Archives of Toxicology·Klaus GolkaJan G Hengstler
Nov 17, 2009·Science in China. Series C, Life Sciences·Courtney ProchnowXiaoJiang S Chen
May 23, 2013·Nature Communications·In-Ja L ByeonAngela M Gronenborn
Sep 30, 2008·Nature Structural & Molecular Biology·Roni NowarskiMoshe Kotler
Jan 12, 2010·Nature Structural & Molecular Biology·Mark D StengleinReuben S Harris
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rodolphe SuspèneSimon Wain-Hobson
Sep 15, 2012·The Journal of Biological Chemistry·Marie-Ming AynaudJean-Pierre Vartanian
Dec 30, 2009·The Journal of Experimental Medicine·Nicoletta CasartelliArnaud Moris
Aug 3, 2011·Human Molecular Genetics·Cailin E JoyceAnne M Bowcock
Nov 29, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael H Malim
Nov 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Linda ChelicoMyron F Goodman
Dec 2, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vincent PetitSimon Wain-Hobson
Sep 16, 2011·Journal of Virology·Celia PeralesJean-Pierre Vartanian
Oct 1, 2011·Journal of Virology·Fransje A KoningMichael H Malim
Jul 10, 2009·Journal of Virology·Fransje A KoningMichael H Malim
Oct 24, 2008·Journal of Virology·Ariana HarariViviana Simon
Mar 30, 2012·Journal of Virology·Marcel OomsCarsten Münk
Jul 25, 2013·Retrovirology·Dragana Slavkovic LukicMartin Löchelt
Jun 10, 2010·PLoS Genetics·Alexander Wait ZaranekGeorge M Church
Jun 5, 2010·PLoS Pathogens·Jean-Pierre VartanianSimon Wain-Hobson
Apr 5, 2013·PLoS Pathogens·John F KriskoJ Victor Garcia
May 24, 2014·PLoS Pathogens·Spyridon StavrouSusan R Ross
Nov 10, 2011·Viruses·Jörg Zielonka, Carsten Münk
Jul 19, 2013·BioMed Research International·Valdimara C Vieira, Marcelo A Soares
Oct 29, 2013·Molecular Biology and Evolution·Vincent CavalSimon Wain-Hobson
Oct 29, 2013·Nucleic Acids Research·Mithun MitraJudith G Levin
Feb 7, 2014·Anti-cancer Drugs·Li-Ching ChangPei-Fung Wu
Apr 3, 2014·British Journal of Cancer·R SuspèneJ-P Vartanian
Oct 22, 2014·Epigenomics·Don-Marc Franchini, Svend K Petersen-Mahrt

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