PMID: 6986184Jan 12, 1980Paper

Evidence for existence of two types of massive obesity

British Medical Journal
P G KopelmanS L Jeffcoate

Abstract

The responses of growth hormone, cortisol, and prolactin to symptomatic hypoglycaemia during an intravenous insulin tolerance test were measured in 20 massively obese subjects and six lean volunteers. In 11 subjects, who had been obese since early childhood, an impaired growth-hormone response and an absent prolactin response were found. In the nine other obese subjects, however, the growth-hormone and prolactin responses were not significantly impaired. Seven of these subjects had become obese either as a teenager or during adult life. These findings suggest the existence of two types of human obesity similar to those found in rodent models. In one the disorder of hypothalamic function may be due to a basic, possibly genetic abnormality, while in the other it is acquired.

References

May 24, 1979·Nature·R T JungB A Callingham
Sep 1, 1976·Endocrinology·Y N SinhaW P Vanderlaan
Mar 1, 1972·The Journal of Clinical Endocrinology and Metabolism·M F BallJ J Canary

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Citations

Sep 24, 1983·British Medical Journal·P G KopelmanD W Empey
Jan 1, 1985·Clinical Endocrinology·A CataniaC Zanussi
Jul 1, 1987·The Proceedings of the Nutrition Society·E M Whitaker
Dec 1, 1994·The Journal of Experimental Zoology·N HisanoS A Calderari
Oct 1, 1988·Journal of the American College of Nutrition·V R LalaR Noto
Dec 1, 1983·Nutrition Reviews·J R VasselliT B Van Itallie

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