Evidence for extrahippocampal involvement in place learning and hippocampal involvement in path integration

Hippocampus
I Q Whishaw, L E Jarrard

Abstract

Although there is a good deal of evidence that animals require the hippocampus for learning place responses, animals with damage to the afferent and efferent fibers coursing through the fimbria-fornix have been shown to acquire a place response. This finding suggests either that the cells of the hippocampus proper (CA1-4 and dentate gyrus), via their connections to the temporal lobe, can mediate place learning or that some extrahippocampal structure is sufficient. We examined this question using rats with ibotenic acid lesions of the cells of the hippocampus. Rats were pretrained to swim to a visible platform and then given probe trials on which the visible platform was removed. Video and kinematic analyses showed that the hippocampal rats expected to find the platform at its previous location because they swam directly to that location and paused and turned at that location after the platform was removed. Additional tests confirmed that they had learned a place response. There were, however, abnormalities in their swimming patterns, and despite having acquired one place response, they did not then acquire new place responses when only the hidden platform training procedure was used. These results demonstrate that place learnin...Continue Reading

References

Apr 1, 1989·Behavioural Brain Research·R J Sutherland, A J Rodriguez
Feb 1, 1984·Behavioural Brain Research·I Q Whishaw, B Kolb
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
Oct 1, 1993·Neuropathology and Applied Neurobiology·L E Jarrard, B S Meldrum
Oct 1, 1993·Neuropsychologia·S J AngeliM Mishkin
Jan 1, 1990·The European Journal of Neuroscience·R. G. M. MorrisL. E. Jarrard

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Citations

Sep 24, 1999·Journal of Neuroscience Research·C Hölscher
Jan 1, 1997·Hippocampus·N M White, M C Ouellet
May 8, 1998·Hippocampus·I Q Whishaw
Nov 24, 1999·Hippocampus·H MaaswinkelI Q Whishaw
May 10, 2001·Hippocampus·J Ferbinteanu, R J McDonald
Nov 5, 2004·Experimental Brain Research·Carole Parron, Etienne Save
Mar 20, 2001·Neuropsychologia·C L WorsleyR G Morris
Jun 5, 2003·Physiology & Behavior·Elisabetta BaldiBucherelli Corrado
Jan 5, 2002·Journal of Neuroscience Methods·Douglas G WallaceIan Q Whishaw
Jun 7, 2000·Behavioural Brain Research·M ModoH Hodges
Feb 13, 2001·Behavioural Brain Research·L B DayW Wilczynski
Nov 24, 2001·Behavioural Brain Research·A D Redish
Oct 19, 2002·Behavioural Brain Research·Edward J Golob, Jeffrey S Taube
Dec 21, 2002·Behavioural Brain Research·Timothy E HohDonald P Cain
Feb 25, 1998·Behavioural Brain Research·I Q Whishaw, J A Tomie
May 2, 2000·Neuroscience Letters·J M CimadevillaJ Bures
Jan 14, 2004·Journal of Comparative Psychology·Lainy Baird DayWalter Wilczynski
Jun 4, 2004·Behavioral Neuroscience·William E DeCoteauRaymond P Kesner
Sep 21, 2000·The European Journal of Neuroscience·J M Ramos
Apr 20, 1999·Neuroreport·B G Cooper, S J Mizumori
Aug 18, 2004·PLoS Biology·Livia de HozRichard G M Morris
Apr 29, 2009·Journal of Visualized Experiments : JoVE·Ian Q Whishaw, Boguslaw P Gorny

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