Evidence for folate-salvage reactions in plants

The Plant Journal : for Cell and Molecular Biology
Giuseppe OrsomandoAndrew D Hanson

Abstract

Folates in vivo undergo oxidative cleavage, giving pterin and p-aminobenzoylglutamate (pABAGlu) moieties. These breakdown products are excreted in animals, but their fate is unclear in microorganisms and unknown in plants. As indirect evidence from this and previous studies strongly suggests that plants can have high folate-breakdown rates (approximately 10% per day), salvage of the cleavage products seems likely. Four sets of observations support this possibility. First, cleavage products do not normally accumulate: pools of pABAGlu (including its polyglutamyl forms) are equivalent to, at most, 4-14% of typical total folate pools in Arabidopsis thaliana, Lycopersicon esculentum and Pisum sativum tissues. Pools of the pterin oxidation end-product pterin-6-carboxylate are, likewise, fairly small (3-37%) relative to total folate pools. Second, little pABAGlu built up in A. thaliana plantlets when net folate breakdown was induced by blocking folate synthesis with sulfanilamide. Third, A. thaliana and L. esculentum tissues readily converted supplied breakdown products to folate synthesis precursors: pABAGlu was hydrolysed to p-aminobenzoate and glutamate, and dihydropterin-6-aldehyde was reduced to 6-hydroxymethyldihydropterin. Fou...Continue Reading

References

Nov 1, 1992·Analytical Biochemistry·J McPartlinJ Scott
Jan 1, 1980·Methods in Enzymology·K G Scrimgeour
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·A R BelloS M Beverley
May 26, 2001·Annual Review of Nutrition·J R SuhP J Stover
May 9, 2002·Journal of Experimental Botany·Michael J FryerNeil R Baker
Jun 11, 2002·Annual Review of Nutrition·Jesse F Gregory, Eoin P Quinlivan
Sep 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gilles BassetAndrew D Hanson
Dec 28, 2002·Journal of Agricultural and Food Chemistry·Lena M StrålsjöMargaretha I Jägerstad
Apr 2, 2003·The Journal of Biological Chemistry·Eoin P QuinlivanAndrew D Hanson
Sep 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rocío Díaz de la GarzaAndrew D Hanson
May 13, 2005·The Journal of Biological Chemistry·Aymeric GoyerAndrew D Hanson
Jun 18, 2005·The Journal of Biological Chemistry·Giuseppe OrsomandoAndrew D Hanson
Jul 16, 1949·Nature·E A FALCO, G H HITCHINGS

❮ Previous
Next ❯

Citations

Sep 28, 2007·Natural Product Reports·Fabrice RébeilléMartin J Warren
May 12, 2012·The Journal of Biological Chemistry·Djeneb CamaraFabrice Rébeillé
Apr 4, 2008·The Journal of Biological Chemistry·Aymerick EudesAndrew D Hanson
Feb 5, 2009·The Journal of Biological Chemistry·Rachel A OkrentMary C Wildermuth
Jan 16, 2007·Plant Physiology·Alexandre NoirielAndrew D Hanson
Jul 25, 2007·BMC Genomics·Valérie de Crécy-LagardAndrew D Hanson
Feb 1, 2011·Annual Review of Plant Biology·Andrew D Hanson, Jesse F Gregory
Sep 26, 2014·Genome Biology and Evolution·Finlay MaguireThomas A Richards
Oct 15, 2011·Phytochemistry·Oscar NavarreteSergei Storozhenko
Dec 18, 2007·Trends in Plant Science·Samir BekaertAndrew D Hanson
Jun 7, 2007·The Plant Journal : for Cell and Molecular Biology·Alexandre NoirielAndrew D Hanson
Nov 13, 2010·The Plant Journal : for Cell and Molecular Biology·Payam MehrshahiDean Dellapenna
Nov 13, 2010·The Plant Journal : for Cell and Molecular Biology·Tariq A AkhtarAndrew D Hanson
Apr 12, 2016·Frontiers in Microbiology·Jennifer J ThiavilleValérie de Crécy-Lagard
Jan 25, 2019·Journal of Mass Spectrometry : JMS·Andrea AnnibalAdam Antebi
Dec 28, 2018·The Journal of Experimental Medicine·Yuxiang Zheng, Lewis C Cantley
Apr 21, 2017·Frontiers in Chemistry·Vera GorelovaDominique Van Der Straeten
Mar 22, 2016·Plant Biotechnology Journal·Naty G Ramírez RiveraRocío Isabel Díaz de la Garza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.