Apr 29, 2020

Asynchrony between virus diversity and antibody selection limits influenza virus evolution

BioRxiv : the Preprint Server for Biology
D. H. MorrisColin A. Russell

Abstract

Seasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variants are rarely selected within-host, even in previously immune individuals. We find that the temporal asynchrony between within-host virus exponential growth and antibody-mediated selection make within-host antigenic adaptation rare. Instead, selection for new antigenic variants acts principally at the point of initial virus inoculation, where small virus populations encounter well-matched mucosal antibodies in previously infected individuals. Selection later in infection is rare. Our results explain how virus antigenic evolution can be highly selective at the global level but nearly neutral within hosts. They also suggest new avenues for improving influenza control.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Study
Genome
RNA, Untranslated
Nucleic Acid Sequencing
Protein Biosynthesis
Proteomics
Genomics
Codon Genus
Codon (Nucleotide Sequence)
Ribosomes

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.