PMID: 9553989Apr 29, 1998Paper

Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanisms

Pharmacology & Toxicology
P Salmi, S Ahlenius

Abstract

The present study was designed to examine 1) functional interactions between 5-HT1A and 5-HT2A/C receptors in thermoregulation in rats and 2) the specific involvement of 5-HT2A and 5-HT2C receptors in such interactions. The 5-HT2A/C receptor agonist DOI (0.025 1.6 mg kg-1, subcutaneously) produced a dose-dependent hyperthermia in rats, which was enhanced by addition of either of two 5-HT1A receptor antagonists, (-)-pindolol (0.5-1.0 mg kg-1, subcutaneously) or WAY-100,635 (0.1-0.4 mg kg-1, subcutaneously). Furthermore, the DOI-induced hyperthermia was counteracted by pretreatment with the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg kg-1, subcutaneously). The hyperthermia produced by DOI, alone or in combination with WAY-100,635, was fully antagonized by pretreatment with the 5-HT2A/C receptor antagonist ritanserin (1.0 mg kg-1, subcutaneously), as well as with the selective 5-HT2A receptor antagonist amperozide (2.0 mg kg-1, subcutaneously). The present results provide evidence for functional interactions between 5-HT1A and 5-HT2A receptors in temperature regulation in rats, and also suggest an important role for postsynaptic 5-HT2A receptors in the mediation of DOI-induced hyperthermia.

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Citations

Jan 17, 2007·Menopause : the Journal of the North American Menopause Society·Aysegul E KalayOmer Kandemir
Aug 19, 2007·The Journal of Pharmacology and Experimental Therapeutics·Daniel E RusyniakJoseph A DiMicco
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Klaas P ZuideveldMeindert Danhof
Jul 18, 2002·Journal of Pineal Research·Mao-Tsun Lin, Jih-Ing Chuang
Jul 19, 2003·Pharmacological Reviews·A Richard GreenM Isabel Colado
Nov 27, 2004·The Journal of Pharmacy and Pharmacology·Aska HayashiKeiji Miyata
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Faïza BenaliouadPierre-Paul Rompré
Oct 14, 2009·Psychopharmacology·Meredith A FoxDennis L Murphy
Aug 8, 2014·International Ophthalmology·Guillermo Salcedo-VillanuevaMaurice B Landers
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Klaas P ZuideveldMeindert Danhof
Apr 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G NevesS M K Rates
Jun 27, 2012·International Journal of Psychiatry in Clinical Practice·Ali GhaleihaNasrin Matinnia
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K P ZuideveldM Danhof
Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris
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