Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease.

PloS One
Filip SimunovicKai C Sonntag

Abstract

Epidemiological data suggest that the male gender is one of the risks factors for the development of Parkinson Disease (PD). Also, differences in the clinical manifestation and the course of PD have been observed between males and females. However, little is known about the molecular aspects underlying gender-specificity in PD. To address this issue, we determined the gene expression profiles of male and female dopamine (DA) neurons in sporadic PD. We analyzed Affymetrix-based microarrays on laser microdissected DA neurons from postmortem brains of sporadic PD patients and age-matched controls across genders. Pathway enrichment demonstrated that major cellular pathways involved in PD pathogenesis showed different patterns of deregulation between males and females with more prominent downregulation of genes related to oxidative phosphorylation, apoptosis, synaptic transmission and transmission of nerve impulse in the male population. In addition, we found upregulation of gene products for metabolic processes and mitochondrial energy consumption in the age-matched male control neurons. On the single cell level, selected data validation using quantitative Real-Time (qRT)-PCR was consistent with microarray raw data and supported so...Continue Reading

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Methods Mentioned

BETA
laser capture microscopy
PCR
Assay
chip
laser-capture
PCA

Software Mentioned

BioCarta
PPEP
SAM
Pathway Pattern Extraction Pipeline
WPS
GSEA

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