Evidence for Genetic Correlations and Bidirectional, Causal Effects Between Smoking and Sleep Behaviors

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Mark GibsonJorien L Treur


Cigarette smokers are at increased risk of poor sleep behaviors. However, it is largely unknown whether these associations are due to shared (genetic) risk factors and/or causal effects (which may be bidirectional). We obtained summary-level data of genome-wide association studies of smoking (smoking initiation [n = 74 035], cigarettes per day [n = 38 181], and smoking cessation [n = 41 278]) and sleep behaviors (sleep duration and chronotype, or "morningness" [n = 128 266] and insomnia [n = 113 006]). Using linkage disequilibrium (LD) score regression, we calculated genetic correlations between smoking and sleep behaviors. To investigate causal effects, we employed Mendelian randomization (MR), both with summary-level data and individual-level data (n = 333 581 UK Biobank participants). For MR with summary-level data, individual genetic variants were combined with inverse variance-weighted meta-analysis, weighted median regression, MR-Robust Adjusted Profile Score, and MR Egger methods. We found negative genetic correlations between smoking initiation and sleep duration (rg = -.14, 95% CI = -0.26 to -0.01) and smoking cessation and chronotype (rg = -.18, 95% CI = -0.31 to -0.06), and positive genetic correlations between smoki...Continue Reading


May 1, 1994·Preventive Medicine·D W Wetter, T B Young
May 5, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S GreenlandS F Lanes
Jun 11, 1998·Psychoneuroendocrinology·B F O'HaraJ D Miller
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benoît Saint-MleuxMauro Serafin
Mar 10, 2005·Addiction·Janet FergusonKen Judge
Jun 23, 2005·Behavior Genetics·Jacqueline M VinkDorret I Boomsma
Oct 7, 2006·Sleep Medicine·Margaret ParkDavid A Bennett
Oct 21, 2006·Current Opinion in Pulmonary Medicine·Rajiv Dhand, Harjyot Sohal
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Jan 10, 2009·Pharmacology, Biochemistry, and Behavior·Ajna Hamidovic, Harriet de Wit
Apr 15, 2010·Sleep Medicine·Michael A GrandnerNalaka Gooneratne
Apr 27, 2010·Nature Genetics·UNKNOWN Tobacco and Genetics Consortium
Nov 11, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer J WareMarcus R Munafò
Oct 23, 2012·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Michael S BusinelleDavid W Wetter
Nov 16, 2013·Epidemiology and Psychiatric Sciences·H H Goldman, M Tansella
Mar 17, 2015·European Journal of Epidemiology·Stephen BurgessUNKNOWN EPIC- InterAct Consortium
May 6, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shumpei NumaguchiYasuaki Tokuhashi
Jun 8, 2015·Lancet·Simon G Thompson, Peter Willeit
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Jul 2, 2015·Sleep·Mackenzie J LindAnanda B Amstadter
Sep 29, 2015·Nature Genetics·Brendan Bulik-SullivanBenjamin M Neale
Nov 18, 2016·Addictive Behaviors·MacKenzie R PeltierDarla E Kendzor
Nov 23, 2016·Trends in Neurosciences·Glenda LassiMarcus R Munafò
May 10, 2017·Sleep Medicine Clinics·Meena S Khan, Rita Aouad
May 27, 2017·Addiction Biology·Tam T Nguyen-LouieSusan F Tapert
Oct 19, 2017·Journal of Public Health·D BoakyeD F Mackay
Nov 7, 2017·Addiction Research & Theory·Nicole A ShortNorman B Schmidt

❮ Previous
Next ❯


Jul 23, 2019·Chronobiology International·Altug DidikogluMaria Mercè Canal
May 22, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew W BergenSean P David
Jul 28, 2020·Brain, Behavior, and Immunity·Yanlong LiuFan Wang
Jul 3, 2021·Brain Sciences·Wojciech HajdusianekPaweł Gać

❮ Previous
Next ❯

Software Mentioned

- Base
R package

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.