Evidence for Genetic Correlations and Bidirectional, Causal Effects Between Smoking and Sleep Behaviors

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Mark GibsonJorien L Treur

Abstract

Cigarette smokers are at increased risk of poor sleep behaviors. However, it is largely unknown whether these associations are due to shared (genetic) risk factors and/or causal effects (which may be bidirectional). We obtained summary-level data of genome-wide association studies of smoking (smoking initiation [n = 74 035], cigarettes per day [n = 38 181], and smoking cessation [n = 41 278]) and sleep behaviors (sleep duration and chronotype, or "morningness" [n = 128 266] and insomnia [n = 113 006]). Using linkage disequilibrium (LD) score regression, we calculated genetic correlations between smoking and sleep behaviors. To investigate causal effects, we employed Mendelian randomization (MR), both with summary-level data and individual-level data (n = 333 581 UK Biobank participants). For MR with summary-level data, individual genetic variants were combined with inverse variance-weighted meta-analysis, weighted median regression, MR-Robust Adjusted Profile Score, and MR Egger methods. We found negative genetic correlations between smoking initiation and sleep duration (rg = -.14, 95% CI = -0.26 to -0.01) and smoking cessation and chronotype (rg = -.18, 95% CI = -0.31 to -0.06), and positive genetic correlations between smoki...Continue Reading

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Citations

Jul 23, 2019·Chronobiology International·Altug DidikogluMaria Mercè Canal
May 22, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrew W BergenSean P David
Jul 28, 2020·Brain, Behavior, and Immunity·Yanlong LiuFan Wang
Jul 3, 2021·Brain Sciences·Wojciech HajdusianekPaweł Gać

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Software Mentioned

- Base
SNiPa
R package
MR
STATA

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