Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting

Neuroendocrinology
S NagataniD L Foster

Abstract

Administration of leptin during undernutrition improves reproductive function, but whether this occurs at the level of the brain, pituitary, or gonads is not yet clear. The present study tested the hypothesis that one important mechanism is the control of pulsatile gonadotropin-releasing hormone (GnRH) secretion. Our approach was to determine if leptin could prevent the marked suppression of pulsatile luteinizing hormone (LH) secretion which occurs during fasting. Leptin (3 micrograms/g i.p.; three times/48 h) or vehicle was administered during a 48-hour fast in adult ovariectomized and estrogen-treated ovariectomized rats (n = 5-7/group). LH was measured in blood samples collected every 6 min for 2 h before and after fasting. In vehicle-treated animals, plasma insulin and leptin levels decreased after fasting. As expected, the LH pulse frequency also decreased markedly. When circulating leptin remained artificially elevated during fasting, the suppression of LH pulse frequency did not occur. Leptin treatment maintained a high LH pulse frequency in the presence or absence of estrogen. The finding that leptin modulates LH pulse frequency indicates that this fat-derived hormone conveys information about nutrition to mechanisms wh...Continue Reading

Citations

Aug 2, 2012·Cellular and Molecular Life Sciences : CMLS·Carol F Elias, Darshana Purohit
Jun 15, 2011·European Journal of Nutrition·Audrey J GaskinsEnrique F Schisterman
Sep 1, 2005·Cellular and Molecular Neurobiology·George SoulisKyriaki Gerozissis
Jul 20, 2007·Reviews in Endocrine & Metabolic Disorders·Gwendolyn W Louis, Martin G Myers
Apr 15, 2005·Brain Research·Patricia S Williamson-HughesM Susan Smith
Jul 15, 1999·Physiology & Behavior·C L Marín-Bivens, D H Olster
Jan 5, 2002·Steroids·Darrell W BrannClint D Buchanan
Jul 20, 2002·Frontiers in Neuroendocrinology·M Susan Smith, Kevin L Grove
Jan 5, 2002·Theriogenology·G D SmithD L Foster
Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Mar 26, 2002·Molecular and Cellular Endocrinology·M Tena-Sempere, M L Barreiro
Mar 2, 2002·Domestic Animal Endocrinology·C R BarbK L Houseknecht
Jan 27, 2000·Cytokine & Growth Factor Reviews·B R LackeyD M Henricks
Oct 7, 2003·Anatomical Science International·Hisayuki FunahashiSeiji Shioda
Apr 23, 2011·Obstetrical & Gynecological Survey·Chiara TersigniNicoletta Di Simone
Jun 9, 2000·Annual Review of Physiology·R S Ahima, J S Flier
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·Wenyu HuangJon E Levine
Dec 1, 2009·International Journal of Pediatric Endocrinology·Ruimin ChenKenneth L McCormick
Sep 14, 2007·Neuroendocrinology·Manuel Tena-Sempere
Nov 26, 2010·Neuroendocrinology·José DonatoCarol F Elias
Jun 19, 2012·Reproductive Biology and Endocrinology : RB&E·Selmo GeberMarcos Sampaio
Jan 31, 2009·Endocrinology·Janette H QuennellGreg M Anderson
Feb 18, 2011·Endocrinology·Janette H QuennellGreg M Anderson
Jun 8, 2012·Endocrinology·Garrett T Gaskins, Suzanne M Moenter
Sep 16, 2003·Medicine and Science in Sports and Exercise·George N Wade, Juli E Jones

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