PMID: 9181340Jan 1, 1996Paper

Evidence for heterogeneity in a small squamous cell type ('light' cells) in the rabbit corneal epithelium--a scanning electron microscope study. Corneal epithelial squamous cells

Documenta Ophthalmologica. Advances in Ophthalmology
M J Doughty

Abstract

The rabbit corneal epithelial surface, as viewed by scanning electron microscopy (SEM), is composed of a mosaic of polygonal cells with different appearances (light, medium and dark) with the lighter cells having a characteristically high density of microplicae. From the central zone of the corneal epithelial surface of 16 female New Zealand White rabbits (2 kg), the lighter-appearing cells had an average area of 108 +/- 47 microns2 (n = 567, +/-SD). A subgroup of atypical lighter cells had an average area of 294 +/- 67 microns2 (n = 53) compared to typical light cells of 88 +/- 12 microns (n = 514). These atypical lighter cells had fused microplicae at their periphery (instead of a uniform arrangement of densely packed microplicae), tended to be rounder in shape (as opposed to being angular), could show signs of desquamation and were not decorated with the epithelial craters found on almost all (92%) other light cells. All of these features are suggestive of these atypical lighter cells being the terminal phenotype of the light cells just prior to desquamation from the ocular surface. The observation of the desquamation of lighter cells supports a hypothesis that they constitute a distinct sub-population of cells at the cornea...Continue Reading

References

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Sep 1, 1994·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M J Doughty
Nov 1, 1995·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·M J Doughty

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Citations

Feb 4, 2006·American Journal of Respiratory Cell and Molecular Biology·Judith A VoynowMary C Rose
Sep 23, 2006·American Journal of Respiratory Cell and Molecular Biology·Irina KouznetsovaWerner Hoffmann
Feb 2, 2008·American Journal of Respiratory Cell and Molecular Biology·Tom N HilliardEric W F W Alton
Sep 2, 2008·American Journal of Respiratory Cell and Molecular Biology·Anna C ZemkeBarry R Stripp
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mark J HoeggerMichael J Welsh
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Susan D ReynoldsBarry R Stripp
Mar 25, 2009·American Journal of Respiratory Cell and Molecular Biology·Luigi AtzoriGiuseppe Lungarella
Aug 21, 2010·American Journal of Respiratory Cell and Molecular Biology·Jeremy A HirotaDarryl A Knight

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