HL-A typing of 150 patients who had developed diabetes mellitus by the age of 30 years showed a significant association with HL-A 8 and W 15. The HL-A genotypes were determined in 17 families in which two or more siblings had this type of diabetes. The zygotic assortment of HL-A haplotypes was found to be significantly disturbed from the expected random pattern, with a reduction in the number of siblings showing no identical haplotypes and an appreciable increase in the number with both haplotypes identical. This appears to be most consistent with the presence of a gene or genes pre-disposing to this type of diabetes at a locus closely linked to the HL-A chromosomal loci. This locus appears to have a fundamental role in the susceptibility to juvenile diabetes.
Incidence, seasonal and geographical patterns of juvenile-onset insulin-dependent diabetes mellitus in Denmark
HLA-typing in juvenile diabetics with and without positive family history and in families with one and two diabetic siblings
Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY)
HLA and GM in insulin-dependent diabetes in the Netherlands: report on a combined multiplex family and population study
Two-disease-locus model: segregation analysis using information on two markers in nuclear families. Application to IDDM
Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.
HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs
Genetic susceptibility to non-insulin dependent diabetes mellitus and glucose intolerance are located in HLA region
Linkage and association of the HLA gene complex with IDDM in 81 Danish families: strong linkage between DR beta 1Lys71+ and IDDM
HLA class II SNP interactions and the association with type 1 diabetes mellitus in Bengali speaking patients of Eastern India
Autoimmune Diabetes & Tolerance
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.