PMID: 9546590Apr 18, 1998Paper

Evidence for HSP70-like protein in the RBC membrane of the hereditarily anemic Belgrade laboratory (b/b) rat

Molecular and Cellular Biochemistry
J ZarićZ Popović

Abstract

We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from cytosol to the RBC membrane. In the normal rat RBCs this happens when those cells are submitted to heat stress conditions. Our study indicates that the presence of hsp70-like protein in the b/b rat RBC plasma membrane is consistent with a primary defect and is not a consequence of life long stress, i.e. hypoxia.

Citations

Jan 20, 2004·The Journal of Biological Chemistry·Christopher T WagnerJerome Connor
Nov 28, 2001·British Journal of Haematology·A TrifunovićZ Popović

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