PMID: 3213436Jan 1, 1988Paper

Evidence for human immunodeficiency virus (HIV) infection of the brain in a patient with aplastic anemia

Acta Neuropathologica
H V VintersC A Wiley

Abstract

A young female patient with a long history of intravenous drug abuse died after a fulminant course of aplastic anemia. At postmortem examination, she was found to have multinucleate giant cells and immunocytochemical evidence of human immunodeficiency virus (HIV) infection of the central nervous system. This case raises the possibility that HIV infection contributed to the patient's aplastic anemia, and suggests that HIV-associated giant cells might be found retrospectively or prospectively within the brains of patients who die of conditions other than those narrowly defined as acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC). It furthermore emphasizes that HIV infection of the nervous system is not necessarily accompanied by clinically apparent neurological disease.

References

Mar 1, 1986·Journal of Neuropathology and Experimental Neurology·C A WileyM B Oldstone
Jan 25, 1986·Medicina clínica·T Pumarola Suñé, C Cordón-Cardó
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C A WileyM B Oldstone
Nov 1, 1986·Journal of Neuropathology and Experimental Neurology·C K PetitoR W Price
Jun 1, 1987·Annals of Neurology·H V Vinters
Nov 7, 1986·JAMA : the Journal of the American Medical Association·M H StolerL M Angerer
Jul 1, 1987·Journal of Neuropathology and Experimental Neurology·M F MeyenhoferL R Sharer
Nov 12, 1987·The New England Journal of Medicine·T R SpitzerM Lederman
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Dec 9, 1983·JAMA : the Journal of the American Medical Association·J L SpivakT C Quinn
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