PMID: 59076Jul 3, 1976

Evidence for hyperoestrogenaemia as a risk factor for myocardial infarction in men

Lancet
G B Phillips

Abstract

Fifteen men who had had a myocardial infarction between the ages of 32 and 42 years were compared with fifteen age-matched healthy men. Seven of the patients had a strikingly slow rate of beard growth, three had evidence of gynaecomastia, and three had a loss of libido. The slow beard growth and decreased libido, and possibly the gynaecomastia, preceded the myocardial infarction. Mean serum oestradiol and oestrone concentrations were significantly increased in the patients, 43.5 +/- 8.8 (standard deviation) and 50.7 +/- 9.5, respectively, compared wth 33.5 +/- 5.5 and 37.5 +/- 5.8 pg/ml in the controls (p less than 0.001). Mean serum testosterone and dihydrotestosterone concentrations were not significantly different in the two groups. Serum oestradiol and oestrone concentrations were directly proportional to each other as were those of testosterone and dihydrotestosterone. These results suggest that the hyperoestrogenaemia preceded the myocardial infarction and that hyperoestrogenaemia may be an important risk factor for myocardial infarction in men.

Citations

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Dec 18, 2009·Nutrition Research and Practice·Chong-Eon LeeKyu-Il Kim
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Apr 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·P van der SalmJ W van Wersch
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Jul 1, 1999·Environmental Health and Preventive Medicine·N ShonoM Nishizumi
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Related Concepts

Estrogen Effect
Infant Gynecomastia
Hypertensive Disease
Subfertility, Male
Increased Libido
Lipids
Myocardial Infarction
Cigar smoker
Sterotate

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