PMID: 59076Jul 3, 1976

Evidence for hyperoestrogenaemia as a risk factor for myocardial infarction in men

G B Phillips


Fifteen men who had had a myocardial infarction between the ages of 32 and 42 years were compared with fifteen age-matched healthy men. Seven of the patients had a strikingly slow rate of beard growth, three had evidence of gynaecomastia, and three had a loss of libido. The slow beard growth and decreased libido, and possibly the gynaecomastia, preceded the myocardial infarction. Mean serum oestradiol and oestrone concentrations were significantly increased in the patients, 43.5 +/- 8.8 (standard deviation) and 50.7 +/- 9.5, respectively, compared wth 33.5 +/- 5.5 and 37.5 +/- 5.8 pg/ml in the controls (p less than 0.001). Mean serum testosterone and dihydrotestosterone concentrations were not significantly different in the two groups. Serum oestradiol and oestrone concentrations were directly proportional to each other as were those of testosterone and dihydrotestosterone. These results suggest that the hyperoestrogenaemia preceded the myocardial infarction and that hyperoestrogenaemia may be an important risk factor for myocardial infarction in men.


Jan 1, 1978·The British Journal of Dermatology·M M HalimJ L Burton
Oct 1, 1989·European Journal of Clinical Investigation·D B JonesP R Wenham
Jun 1, 1986·Journal of the American Geriatrics Society·W R Hazzard
Dec 18, 2009·Nutrition Research and Practice·Chong-Eon LeeKyu-Il Kim
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D S FreedmanJ J Barboriak
Apr 1, 1977·Klinische Wochenschrift·J Girndt, F Scheler
Nov 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A L Lin, S A Shain
Apr 1, 1994·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·P van der SalmJ W van Wersch
May 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·G B PhillipsT Y Jing
Jul 1, 1999·Environmental Health and Preventive Medicine·N ShonoM Nishizumi
Nov 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·G B PhillipsT Y Jing
May 21, 1998·Journal of Cardiovascular Pharmacology·P AndersenI Holme
Jan 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·B ZumoffD K Fukushima
Apr 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J W YarnellD Riad-Fahmy
Feb 7, 1981·British Medical Journal·R F HellerJ P Deslypere
Sep 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A L LinS A Shain
Jul 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M SewdarsenR Desai

Related Concepts

Estrogen Effect
Infant Gynecomastia
Hypertensive Disease
Subfertility, Male
Increased Libido
Myocardial Infarction
Cigar smoker

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