PMID: 1503450Apr 1, 1992

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci

Antimicrobial Agents and Chemotherapy
M ArthurP Courvalin

Abstract

The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro. D-Lactate added to the culture medium restored the vancomycin resistance of a strain that does not produce the VanH dehydrogenase and therefore appears to be a substrate of VanA in vivo.

Citations

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Related Concepts

Antibiotic Resistance, Microbial
Lactates
Fungus Drug Sensitivity Tests
Pseudomurein
AB-Vancomycin
Enterococcus faecium
Lactate

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