PMID: 11335059May 4, 2001Paper

Evidence for increased extracellular K(+) as an important mechanism for dorsal root induced alternating rhythmic activity in the neonatal rat spinal cord in vitro

Neuroscience Letters
C MarchettiAndrea Nistri

Abstract

Intracellular recording from rat lumbar motoneurones showed that patterned electrical stimulation of one dorsal root induced alternating patterns typical of fictive locomotion, accompanied by a reduction in the antidromic spike afterhyperpolarization (AHP). Since the AHP depended linearly on extracellular K(+) ([K(+)](o)), from the AHP fall we calculated that [K(+)](o) rose to 7.9+/-0.4 mM, a value within the 7-10 mM range known to elicit fictive locomotion. To confirm the specificity of this approach we also tested concentrations of N-methyl-D-aspartate (2 microM) below threshold for fictive locomotion, and we observed that, despite strong excitation, the estimated [K(+)](o) was 6 mM, i.e. outside the range for fictive locomotion. We suggest that synaptic activity induced by a certain pattern of electrical stimulation of afferent fibres evoked persistent elevation in [K(+)](o) which triggered the locomotor network to generate rhythmic patterns.

References

Oct 1, 1975·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
Aug 31, 1992·Neuroscience Letters·A J BergerF Viana
Aug 1, 1974·Canadian Journal of Physiology and Pharmacology·K Krnjević, M E Morris
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Feb 3, 1999·Annals of the New York Academy of Sciences·O Kiehn, O Kjaerulff

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Citations

Oct 10, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Nejada DinguGiuliano Taccola
Jul 31, 2003·The European Journal of Neuroscience·Ilya A RybakOlivier Pierrefiche
Apr 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Frédéric BrocardLaurent Vinay
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Walter M St -JohnJulian F R Paton
Sep 4, 2015·Physiology·Aklesso KadalaArlette Kolta
Mar 13, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Francesco Dose, Giuliano Taccola
Feb 20, 2020·Journal of Neurophysiology·Morgan M HighlanderSherif M Elbasiouny

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