PMID: 8969944Nov 1, 1996Paper

Evidence for independent modulation of human 11-HSD and 5 alpha/5 beta reductase activities

Endocrine Research
P W Raven, N F Taylor

Abstract

The increased ratio of 5 alpha to 5 beta reduced steroids associated with apparent mineralocorticoid excess (AME) may be a necessary consequence of altered 11 beta-hydroxysteroid dehydrogenase (11-HSD) activity. In order to test this hypothesis we have compared changes in 11-HSD activity and 5 alpha/5 beta reduction in a variety of clinical and experimental conditions. The ratio of 11-oxo/11 beta-hydroxy metabolites of cortisol (11-oxo/11-OH FM) was used as an index of 11-HSD activity and the ratio of allotetrahydrocortisol/ tetrahydrocortisol (allo THF/THF) was used as an index of 5 alpha/5 beta reduction. Ratios were derived from 24 hour urinary steroid profiles measured by high resolution gas chromatography. The clinical conditions studied were Cushing's Syndrome, Major Depression and hirsutism. In each study, the patient group were compared with age-matched healthy controls. For the experimental conditions, subjects treated with either hydrocortisone, dexamethasone, metyrapone or finasteride acted as their own controls. No consistent relationship was found between changes in the ratios of 11-oxo/11-OH FM and allo THF/THF. We conclude that there is no evidence of consistent metabolic interaction between 11-HSD and 5 alpha/5 ...Continue Reading

Citations

Jun 13, 2002·European Journal of Clinical Investigation·A AudigéB Vogt
Jul 27, 2006·Psychosomatic Medicine·Walid K JerjesAnthony J Cleare
Jan 28, 2006·Journal of Psychosomatic Research·Walid K JerjesAnthony J Cleare

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