PMID: 5257005Mar 1, 1969Paper

Evidence for intergenic complementation in hybrid cells derived from two human diploid strains each carrying an X-linked mutation

Proceedings of the National Academy of Sciences of the United States of America
M SiniscalcoJ E Seegmiller

Abstract

Two male diploid fibroblast strains, each carrying deficiency mutations at different X-linked loci (glucose-6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyltransferase) have been successfully hybridized. The resulting mononucleated hybrid cells have been shown to synthesize both normal gene products, indicating that both X chromosomes are functionally active in the hybrid cells. We believe this is the first reported example of intergenic complementation in fused human diploid cells.

References

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Sep 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·B B KnowlesH Koprowski
Feb 1, 1963·Biochemical Pharmacology·P STUTTS, R W BROCKMAN
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Citations

Jul 1, 1984·Somatic Cell and Molecular Genetics·S T Warren, R L Davidson
May 1, 1980·Somatic Cell Genetics·B Kahan, R DeMars
Jul 1, 1970·In Vitro·J W Littlefield, S Goldstein
Jan 1, 1992·Electron Microscopy Reviews· Kerkis AYu, N S Zhdanova
Oct 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H L NadlerM Rachmeler
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C Ceccarini, H Eagle
Nov 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J D SharpM R Capecchi
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·B R MigeonC M Corsaro
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B Kahan, R DeMars
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D EspositoM Siniscalco
Jun 1, 1970·The Journal of Experimental Medicine·E RobbinsH Eagle
Jun 18, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Zenon Steplewski, Thomas Kieber-Emmons
May 1, 1970·Experimental Cell Research·F H RuddleS Silagi
Nov 1, 1971·Experimental Cell Research·M H Vaughan, M W Steele
Dec 1, 1971·The Journal of Pediatrics·B R Migeon
Sep 28, 1989·Nature·L Luzzatto
Dec 1, 1972·Journal of Cellular Physiology·E K Sell, R S Krooth
Aug 1, 1973·Journal of Cellular Physiology·J W Littlefield
Dec 1, 1970·Journal of Cellular Physiology·R S Krooth, E K Sell
Oct 1, 1973·Journal of Cellular Physiology·L A Chasin
Nov 3, 1971·Nature: New Biology·A WesterveldD Bootsma
Jul 19, 1972·Nature: New Biology·E A De Weerd-KasteleinD Bootsma

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