PMID: 2122459Nov 1, 1990Paper

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver

Proceedings of the National Academy of Sciences of the United States of America
L M ForresterC R Wolf

Abstract

Liver cancer is a major cause of premature death in many areas of Africa and Asia and its incidence is strongly correlated with exposure to aflatoxin B1 (AFB1). Because AFB1 requires metabolic activation to achieve a biological response, there is a need for detailed knowledge of the mechanism of activation to assess individual risk. We have carried out an extensive study using a total of 19 human liver samples to determine the individual variability in the metabolism of the toxin to mutagenic or detoxification products and to identify the specific cytochrome P-450 forms involved in these processes. Metabolism to the toxic 8,9-epoxide or to products mutagenic in the Ames test was found to exhibit very large individual variation. The rates of metabolic activation were highly correlated with both the level of proteins of the P450IIIA gene family and with the total cytochrome P-450 content of the microsomes. In agreement with this, antibodies reacting with P450IIIA proteins were strong inhibitors of both the metabolism and mutagenicity in the majority of the samples. However, the inhibition varied between 50% and 100%. The expression of a protein in the P450IIC gene family also correlated with AFB1 metabolism and mutagenicity. This...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T Shimada, F P Guengerich
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A D LewisC R Wolf
Jun 1, 1984·Carcinogenesis·C C Harris, T Sun
Mar 16, 1983·Biochemical and Biophysical Research Communications·C R Wolf, F Oesch
Jul 29, 1983·Biochemical and Biophysical Research Communications·K O'BrienG Neal
Jan 1, 1981·Environmental Mutagenesis·E ZeigerI G Robertson
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D E RyanW Levin

❮ Previous
Next ❯

Citations

Jan 1, 1994·Archives of Toxicology·P PelkonenM Pasanen
Oct 1, 1994·Chemico-biological Interactions·P PelkonenM A Lang
Jul 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J AllenB M Greenwood
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·N A AnkrahF A Ekuban
Feb 1, 1995·Pharmacology & Therapeutics·M McLean, M F Dutton
Dec 1, 1993·Mutation Research·P CassandJ F Narbonne
Nov 1, 1994·European Journal of Pharmacology·P PelkonenR O Juvonen
Mar 1, 1994·Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology·H Raza, W Montague
Nov 11, 2003·Free Radical Biology & Medicine·Rheal A TownerRonald P Mason
Apr 16, 2003·Analytical Biochemistry·Lilian G YengiC Roland Wolf
May 10, 2003·Life Sciences·Guillermo Elizondo, Irma M Medina-Díaz
May 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C CavinB Schilter
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C CavinB Schilter
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P J KleinR A Coulombe
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D E GoegerK E Anderson
Jul 10, 2003·Toxicology Letters·Monica Sabater VilarJohanna Fink-Gremmels
Jul 25, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M E KuilmanJ Fink-Gremmels
Dec 22, 1998·Mutation Research·A HakuraT Satoh
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A M PfeiferB F Trump
Jun 25, 2002·Journal of Toxicology and Environmental Health. Part a·Terry R Van VleetRoger A Coulombe
May 9, 2008·Critical Reviews in Food Science and Nutrition·Sunitha Elizabeth GeorgeLingamallu Jagan Mohan Rao
Jul 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tsuyoshi Yokoi, Miki Nakajima
Oct 29, 2010·Journal of Occupational Medicine and Toxicology·Céline GasnierGilles-Eric Séralini
Jul 3, 2013·Toxins·Tomonori InoueNaoki Mochizuki
Nov 20, 2012·Hepatitis Monthly·Hui Chen Wu, Regina Santella
Mar 10, 2001·Biochemical and Biophysical Research Communications·Y HuangT Kodama
Jul 17, 2014·Archives of Toxicology·Vlastimil DohnalKamil Kuča

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.