PMID: 8941759Apr 1, 1996Paper

Evidence for involvement of superantigens in human periodontal diseases: skewed expression of T cell receptor variable regions by gingival T cells

Oral Microbiology and Immunology
H H Zadeh, D L Kreutzer

Abstract

Immunomodulation by periodontopathic bacteria has been implicated in the pathogenesis of inflammatory periodontal diseases. A novel class of microbial-derived T cell mitogens, referred to as superantigens, has recently been described. Superantigens are unique in that they induce a tremendous activation and expansion of specific subsets of T cells in an antigen-independent manner, thereby causing immune dysfunction. Subsets of superantigen-expanded T cells can be identified with reagents that discriminate among different families of the variable domains of the T cell antigen receptor beta-chain (V beta). Since superantigens expand one or a few of these T cell antigen receptor V beta families, T cell subsets that have been expanded by superantigens have restricted expression of one or a few V beta families. In the present study, we investigated the presence of putative superantigen-stimulated T cells in periodontitis sites, utilizing a panel monoclonal antibodies to T cell antigen receptor V beta families. Leukocytes were isolated from gingival tissues obtained from 8 periodontitis and 4 non-periodontitis patients by collagenase digestion. Three-color flow cytometric analysis of these gingival cells demonstrated that in most peri...Continue Reading

References

May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J AbeD Y Leung
Aug 1, 1992·Current Opinion in Immunology·B Fleischer
Aug 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Zumla
Aug 1, 1991·Immunology Today·B C Cole, C L Atkin
Jun 1, 1990·The Journal of Clinical Investigation·D N PosnettL F Mayer
Feb 1, 1990·Oral Microbiology and Immunology·T E RamsJ Slots
Sep 1, 1990·The Journal of Experimental Medicine·Y ChoiB L Kotzin
Mar 1, 1989·Journal of Periodontal Research·H X Meng, L F Zheng
Mar 1, 1987·Journal of Periodontal Research·E D StoufiD J Smith
Jun 1, 1988·Oral Microbiology and Immunology·J SlotsM A Listgarten
May 1, 1987·Journal of Clinical Immunology·E D StoufiP P Stashenko
Apr 1, 1994·Immunity·J D OhmenR L Modlin
Oct 1, 1993·Oral Microbiology and Immunology·M J Flynn, J Slots
Jun 23, 1993·Annals of the New York Academy of Sciences·J LaurenceD N Posnett
Jan 1, 1993·Advances in Immunology·B L KotzinP Marrack
Mar 1, 1993·The Journal of Investigative Dermatology·D Y LeungD A Norris

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Citations

Apr 12, 2000·Clinical and Experimental Immunology·K YamazakiG J Seymour
Jan 1, 1999·Oral Microbiology and Immunology·E GemmellG J Seymour
Dec 12, 1997·European Journal of Oral Sciences·D R GeatchJ J Taylor
Aug 19, 2000·Infection and Immunity·K P Leung, B A Torres
Aug 3, 2006·Journal of Periodontology·C G Dileep Sharma, A R Pradeep
Sep 1, 2005·Journal of Clinical Periodontology·Tord Berglundh, Mauro Donati
Mar 28, 2013·Geriatrics & Gerontology International·Rupali Agnihotri, Sumit Gaur
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G Suchett-KayeO Barsotti
Aug 9, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Yen-Tung A Teng
Apr 27, 2004·Periodontology 2000·Kazuhisa Yamazaki, Takako Nakajima
Mar 27, 1999·Oral Microbiology and Immunology·T NakajimaK Hara
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A Mathur, B S Michalowicz
Feb 13, 2001·Journal of Clinical Periodontology·T BerglundhJ Lindhe
Nov 21, 1997·Clinical and Experimental Immunology·A WassenaarF Kievits

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