Abstract
Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we evaluated the effects of combined treatment of triadimefon with either the tyrosine hydroxylase inhibitor d,l-alpha-methyl-p-tyrosine methyl ester HCl (alpha MPT) or the amine depletor reserpine. Adult male Long-Evans hooded rats, approximately 70 days of age were used. Dosage-effect functions were determined for alpha MPT (0-200 mg/kg IP), reserpine (0-2.5 mg/kg IP), d-amphetamine (0-3 mg/kg IP), and methylphenidate (0-40 mg/kg IP). Motor activity was measured as photocell interruptions in figure-eight mazes. The interaction between triadimefon and alpha MPT was determined with the following groups: 1) vehicle control; 2) 200 mg/kg triadimefon PO; 3) 100 mg/kg alpha MPT; and 4) both alpha MPT and triadimefon. A similar design was used to determine the interaction between triadimefon and reserpine (0.62 mg/kg), alpha MPT and d-amphetamine (1.5 mg/kg), and reserpine and methylphenidate (5.0 mg/kg). In the first experim...Continue Reading
References
Aug 1, 1977·The Journal of Pharmacy and Pharmacology·C Braestrup
Oct 31, 1978·Psychopharmacology·M Sansone
Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·E Widerlöv, T Lewander
Sep 12, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·E Widerlöv, T Lewander
Dec 1, 1975·Environmental Health Perspectives·L W ReiterD F Cahill
Jan 1, 1975·Psychoneuroendocrinology·R T Lobl
Feb 1, 1988·Journal of Neurochemistry·S P ButcherG W Arbuthnott
Sep 1, 1985·Bulletin of Environmental Contamination and Toxicology·C K Winter, P H Kurtz
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·P J Bushnell
Apr 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K M CroftonL W Reiter
Apr 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·R NiddamS Z Langer
Sep 1, 1973·Neuropharmacology·J E Thornburg, K E Moore
Mar 21, 1974·Psychopharmacologia·A S HollisterB R Cooper
Jan 1, 1971·European Journal of Pharmacology·J Scheel-Krüger
Jan 1, 1967·Psychopharmacologia·M K MenonJ S Bapna
Jul 1, 1968·Biochemical Pharmacology·H H Frey, M P Magnussen
Jan 1, 1967·European Journal of Pharmacology·N E Andén
Nov 15, 1980·Biochemical Pharmacology·B A McMillenP A Shore
Jan 1, 1982·Psychopharmacology·D E Brenneman, C O Rutledge
Jan 1, 1984·Psychopharmacology·M K MenonV G Haddox
Mar 15, 1984·Toxicology and Applied Pharmacology·J B KnaakB W Wilson
Dec 1, 1980·Pharmacology, Biochemistry, and Behavior·R G FesslerH Y Meltzer
Jul 1, 1981·Neuropharmacology·H E WardJ J Freeman
Dec 1, 1963·Acta Physiologica Scandinavica·A CARLSSONE ROSENGREN
Citations
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·A N PerkinsR C MacPhail
Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·A R Allen, R C MacPhail
Mar 1, 1996·Toxicology Letters·K M Crofton
May 1, 1989·Neurotoxicology and Teratology·V C Moser, R C MacPhail
Jul 1, 1993·Neurotoxicology and Teratology·A R Allen, R C MacPhail
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Ruth ReevesDeborah A Cory-Slechta
Nov 26, 2003·Neurotoxicology·R ReevesD A Cory-Slechta
Jun 1, 1995·Journal of Toxicology and Environmental Health·V C MoserR C MacPhail
Jun 1, 1995·Journal of Toxicology and Environmental Health·R C MacPhailM Schlicht
Mar 15, 2011·Behavioural Brain Research·John M HoldenVanessa Ehlers
Feb 24, 2009·Ecotoxicology and Environmental Safety·M B SantanaL R F Faro
Mar 1, 1990·Toxicology and Applied Pharmacology·Q D WalkerR B Mailman
Aug 10, 2000·Brain Research·M ThiruchelvamD A Cory-Slechta
Dec 5, 2012·The Journal of Toxicological Sciences·Lilian R Ferreira FaroRafael Durán
Nov 21, 2000·Annals of the New York Academy of Sciences·D HillK F Soliman