PMID: 2497480Jan 1, 1989Paper

Evidence for monoaminergic involvement in triadimefon-induced hyperactivity

Psychopharmacology
K M CroftonR C MacPhail

Abstract

Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we evaluated the effects of combined treatment of triadimefon with either the tyrosine hydroxylase inhibitor d,l-alpha-methyl-p-tyrosine methyl ester HCl (alpha MPT) or the amine depletor reserpine. Adult male Long-Evans hooded rats, approximately 70 days of age were used. Dosage-effect functions were determined for alpha MPT (0-200 mg/kg IP), reserpine (0-2.5 mg/kg IP), d-amphetamine (0-3 mg/kg IP), and methylphenidate (0-40 mg/kg IP). Motor activity was measured as photocell interruptions in figure-eight mazes. The interaction between triadimefon and alpha MPT was determined with the following groups: 1) vehicle control; 2) 200 mg/kg triadimefon PO; 3) 100 mg/kg alpha MPT; and 4) both alpha MPT and triadimefon. A similar design was used to determine the interaction between triadimefon and reserpine (0.62 mg/kg), alpha MPT and d-amphetamine (1.5 mg/kg), and reserpine and methylphenidate (5.0 mg/kg). In the first experim...Continue Reading

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Citations

Dec 1, 1991·Pharmacology, Biochemistry, and Behavior·A N PerkinsR C MacPhail
May 1, 1989·Neurotoxicology and Teratology·V C Moser, R C MacPhail
Jul 1, 1993·Neurotoxicology and Teratology·A R Allen, R C MacPhail
Nov 1, 2003·Pharmacology, Biochemistry, and Behavior·Ruth ReevesDeborah A Cory-Slechta
Nov 26, 2003·Neurotoxicology·R ReevesD A Cory-Slechta
Jun 1, 1995·Journal of Toxicology and Environmental Health·V C MoserR C MacPhail
Jun 1, 1995·Journal of Toxicology and Environmental Health·R C MacPhailM Schlicht
Mar 15, 2011·Behavioural Brain Research·John M HoldenVanessa Ehlers
Mar 1, 1990·Toxicology and Applied Pharmacology·Q D WalkerR B Mailman
Nov 21, 2000·Annals of the New York Academy of Sciences·D HillK F Soliman

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