Evidence for multiple alleles at the DGAT1 locus better explains a quantitative trait locus with major effect on milk fat content in cattle

Genetics
C KühnR Fries

Abstract

A quantitative trait locus (QTL) for milk fat percentage has been mapped consistently to the centromeric region of bovine chromosome 14 (BTA14). Two independent studies have identified the nonconservative mutation K232A in the acylCoA-diacylglycerol-acyltransferase 1 (DGAT1) gene as likely to be causal for the observed variation. Here we provide evidence for additional genetic variability at the same QTL that is associated with milk fat percentage variation within the German Holstein population. Namely, we show that alleles of the DGAT1 promoter derived from the variable number of tandem repeat (VNTR) polymorphism are associated with milk fat content in animals homozygous for the allele 232A at DGAT1. Our results present another example for more than two trait-associated alleles being involved in a major gene effect on a quantitative trait. The segregation of multiple alleles affecting milk production traits at the QTL on BTA14 has to be considered whenever marker-assisted selection programs are implemented in dairy cattle. Due to the presence of a potential transcription factor binding site in the 18mer element of the VNTR, the variation in the number of tandem repeats of the 18mer element might be causal for the variability i...Continue Reading

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Citations

Oct 7, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Eveline M Ibeagha-AwemuXin Zhao
Apr 10, 2010·Animal Biotechnology·Marcos Vinicius G Barbosa da SilvaCurt P Van Tassell
Sep 2, 2008·Journal of Lipid Research·Chi-Liang Eric YenRobert V Farese
Oct 12, 2012·Genetics and Molecular Biology·Ashwin A RautAnamika Mishra
Dec 2, 2008·International Journal of Biological Sciences·Tito A WibowoZhihua Jiang
May 9, 2008·DNA Sequence : the Journal of DNA Sequencing and Mapping·R T VenkatachalapathyTarun K Bhattacharya
Aug 4, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D KolbehdariS S Moore
Sep 3, 2011·Reproduction in Domestic Animals = Zuchthygiene·D-S ShiQ-Y Liu
Dec 25, 2010·Journal of Dairy Science·E M StruckenG A Brockmann
Oct 2, 2014·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Lucimar Souza AmorimGeorge Rêgo Albuquerque
Jan 1, 2009·Genetics and Molecular Biology·Marina R S FortesHenrique N de Oliveira
Jul 1, 2009·Genetics and Molecular Biology·María C MiquelAlejandro Schor
Sep 21, 2007·Journal of Dairy Science·A P W de RoosR F Veerkamp
Mar 29, 2014·Molecular Biology Reports·Izinara da Cruz RosseMaria Raquel Santos Carvalho
Feb 23, 2017·Genetics, Selection, Evolution : GSE·Hubert PauschMichael E Goddard
Dec 30, 2017·BMC Genomics·Mirjam FrischknechtBirgit Gredler-Grandl

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