Nov 1, 1977

Evidence for multiple cell surface chicken fetal-leukemic antigens (CFA) in the developing chick and other avian species

The Journal of Experimental Zoology
R R Dietert, B G Sanders


Chicken fetal antigen (CFA), a membrane antigen present on fetal chicken red blood cells is lost with chicken development, and reappears on the red blood cells of leukemic chickens. Seven avian species were found to possess CFA. A species hierarchy comparing the quantitative expression of CFA has been established. The levels of CFA expression with development are compared in the chicken and Japanese quail. Specific adsorptions of R-anti-CFA with avian red blood cells revealed the existence of multiple CFAs. Four groups of antigenic determinants (CFA a,b,c,d) have been characterized and defined by their expression among avian species. Multiple CFA determinants are discussed with regard to possible membrane alterations and gene function.

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Mentioned in this Paper

Antigenic Specificity
Hairy Cell Leukemia
Avian Leukosis
Chick Embryo
Tumor Antigens
Plasma Membrane
Japanese Quail

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