PMID: 9545016Apr 17, 1998Paper

Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study

Obesity Research
I B BoreckiMichael A Province

Abstract

The body mass index (BMI) is a complex phenotype representing the amount of fat mass, lean mass, body build and proportions, and it is likely to be affected by various metabolic processes, hormonal effects, energy intake and expenditure, and interactions within and among these broad categories of etiologic factors. Nonetheless, several previous studies have reported evidence for major gene segregation for the BMI in various populations. Data on a random sample of Caucasian families participating in the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study were analyzed to document the extent of familial resemblance and to investigate whether a similar monogenic inheritance pattern could be detected. Genetic analysis was carried out on age- and sex-adjusted BMI values. Familial correlations were significant implying a maximal heritability, including all genetic and environmentally inherited additive factors, of 41% to 59%. Segregation analysis revealed the presence of two maximum likelihood solutions, one characterized as a recessive Mendelian gene and the other as a major effect with an ambiguous transmission pattern. The presence of two such solutions is consistent with detection of two separate factors, each in...Continue Reading

References

Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Nov 1, 1989·American Journal of Medical Genetics·S J HasstedtR R Williams
Jan 1, 1988·Annual Review of Nutrition·C Bouchard, L Pérusse
Apr 1, 1988·The American Journal of Clinical Nutrition·L PérusseC Bouchard
Oct 1, 1985·Metabolism: Clinical and Experimental·J P DesprésC Bouchard
Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith
Jan 1, 1984·Metabolism: Clinical and Experimental·D J EvansA H Kissebah
Feb 1, 1983·American Journal of Medical Genetics·W R WilliamsN E Morton
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A H KissebahP W Adams
Jan 1, 1981·Human Heredity·J M Lalouel, N E Morton
Feb 8, 1995·JAMA : the Journal of the American Medical Association·W C WillettC H Hennekens
Jan 1, 1995·Genetic Epidemiology·A G ComuzzieJ W MacCluer
Mar 1, 1996·Metabolism: Clinical and Experimental·L PérusseC Bouchard
Jun 15, 1996·American Journal of Epidemiology·M HigginsR Williams
Jan 1, 1995·Genetic Epidemiology·L D AtwoodN C Stowell
Aug 1, 1996·Current Opinion in Lipidology·R J GarrisonW B Kannel
Nov 22, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T RiceC Bouchard
Oct 1, 1984·Ancient Science of Life·G V Gopal

❮ Previous
Next ❯

Citations

Nov 5, 1999·JAMA : the Journal of the American Medical Association·A H MokdadJ P Koplan
Jun 28, 2011·Human Genetics·Li-Jun TanHong-Wen Deng
May 2, 2008·Maternal and Child Health Journal·Connie L BishHeidi Michels Blanck
Jan 15, 2013·The British Journal of Nutrition·Tania Reyes-IzquierdoZb Pietrzkowski
Sep 6, 2002·Journal of General Internal Medicine·Martin Binks, Mahlen Patrick O'Neil
Jun 6, 1998·The New England Journal of Medicine·R Jain
Apr 6, 2011·Research Quarterly for Exercise and Sport·Zan GaoHuiping Sheng
Jul 11, 2001·Journal of Women's Health & Gender-based Medicine·K R FontaineD B Allison
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Richard C Adler
Mar 23, 2007·Journal of Gastroenterology and Hepatology·Hong Joo KimByung Ik Kim
Jul 17, 2004·Annals of Nutrition & Metabolism·Josep A TurAntoni Pons
Jul 26, 2006·Annals of Nutrition & Metabolism·D RomagueraJ A Tur
Dec 19, 2013·PloS One·William R YatesLisa A Cannon-Albright
Dec 19, 2001·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·H W DengR R Recker
Nov 21, 2008·Nutrition Reviews·Lu Qi, Young Ae Cho
Feb 3, 2005·Obesity Research·Peng-Yuan LiuHong-Wen Deng
Jan 5, 2005·Clinical Cornerstone·Daniel E Hale
Oct 9, 2001·American Journal of Human Genetics·C OberM S McPeek
Jan 26, 2000·Journal of the American Dietetic Association·M M RichardsS C Hunt
Apr 20, 2001·American Journal of Human Genetics·M AbneyC Ober
Jan 23, 1999·American Journal of Human Genetics·J H LeeR A Price
Jan 24, 2004·American Journal of Human Genetics·Rector AryaMichael P Stern
Apr 2, 2002·American Journal of Human Genetics·Hong-Wen DengRobert R Recker
Aug 27, 1998·American Journal of Human Genetics·I B BoreckiD C Rao
Mar 3, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·W ChenG S Berenson
Jan 25, 2012·The American Journal of Gastroenterology·Max SchmulsonGabriela Gutiérrez-Reyes
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A LukeR S Cooper
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ping AnD.C. Rao
Oct 31, 2012·Maternal and Child Health Journal·Candace Mulready-Ward, Judith Sackoff

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.