Evidence for multiple sites within rat ventral striatum mediating cocaine-conditioned place preference and locomotor activation

The Journal of Pharmacology and Experimental Therapeutics
Laurie H L SellingsPaul B S Clarke

Abstract

Considerable evidence suggests that psychostimulants can exert rewarding and locomotor-stimulating effects via increased dopamine transmission in the ventral striatum. However, the relative contributions of ventral striatal subregions to each of these effects have been little investigated. In the present study, we examined the contribution of different ventral striatal sites to the rewarding and locomotor-activating effects of cocaine. Initially, the effects of bilateral 6-hydroxydopamine lesions of the nucleus accumbens core or medial shell on cocaine-induced locomotor stimulation (0.5-1.5 mg/kg i.v. or 5-20 mg/kg i.p.) and conditioned place preference (0.5 mg/kg i.v. or 10 mg/kg i.p.) were examined. In a subsequent study, we investigated the effects of olfactory tubercle versus medial shell lesions on cocaine-conditioned place preference and locomotor activity (0.5 mg/kg i.v.). Dopaminergic lesion extent was quantified by radioligand binding to the dopamine transporter. Multiple linear regression was used to identify associations between behavioral effects and residual dopamine innervation in ventral striatal subregions. On this basis, the accumbens core was associated with the locomotor stimulant effects of i.v. and i.p. coc...Continue Reading

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Citations

Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeff A BeelerXiaoxi Zhuang
Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zhong-Hua LiuSatoshi Ikemoto
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer M WrightPaul B S Clarke
Apr 3, 2012·Zoological Research·Xiao-Fen LiuSu-Dong Guan
Dec 25, 2012·Pharmacology, Biochemistry, and Behavior·Tracey L WheelerRobert F Smith
Dec 18, 2015·Psychopharmacology·Elizabeth N Holly, Klaus A Miczek
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Nov 4, 2008·Pharmacology, Biochemistry, and Behavior·Miriam Garcia-MijaresMaria Teresa Araujo Silva
Oct 20, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gianluigi Tanda
Aug 16, 2008·The European Journal of Neuroscience·Laurie H L SellingsPaul B S Clarke
Sep 19, 2006·Neuroscience Letters·Manoranjan S D'Souza, Christine L Duvauchelle
Apr 13, 2013·Behavioural Brain Research·Ju Kyong JangJeong-Hoon Kim
Dec 29, 2017·Genes, Brain, and Behavior·R J OliverN I Perrone-Bizzozero
May 28, 2019·Molecular Neurobiology·Julianna KardosLászló Héja
Dec 29, 2007·CNS Spectrums·Henk J Groenewegen, Michael Trimble
Dec 24, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adele StewartRandy D Blakely

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