PMID: 7547225Oct 1, 1995Paper

Evidence for mutual interdependence of epithelium and stromal lymphoid cells in a subset of papillary carcinomas

British Journal of Cancer
M H TakahashiE D Williams

Abstract

We have correlated the morphological features of 30 human thyroid carcinomas with the cellular localisation of insulin-like growth factor 1 (IGF-1) mRNA and IGF-1 receptor peptide using in situ hybridisation with digoxigenin-labelled oligoprobes and immunohistochemistry. Four of the five follicular carcinomas studied showed a consistent, uniform, strong positivity for IGF-1 mRNA in tumour cells compared with weakly positive surrounding normal follicular tissue and negative stroma. The majority of papillary carcinomas showed weak to moderate epithelial positivity for IGF-1 mRNA and negative stroma. Immunohistochemistry for IGF-1 receptor showed moderate positivity confined to the tumour epithelial cells in both follicular and the majority of papillary carcinomas. However, in a subgroup of papillary carcinomas characterised by a diffuse stromal lymphoid infiltration (n = 5), the stromal cells showed a much stronger reactivity for IGF-1 mRNA than the tumour or background thyroid, and the tumour cells showed a uniformly high level of immunoreactivity for IGF-1 receptor. These results are compatible with the growth of the papillary carcinoma in these cases being the result of a symbiotic relationship between the stromal lymphoid cel...Continue Reading

Citations

Apr 22, 1999·The Journal of Pathology·R KatohE D Williams
Jan 5, 2011·Breast Cancer Research and Treatment·Rulla M TamimiStuart J Schnitt
Jul 12, 2014·Thyroid : Official Journal of the American Thyroid Association·Florence RenaudEmmanuelle Leteurtre
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·E MaioranoE Perlino
Jan 5, 2013·Endocrine·Ying-Jian LiuBing-Yin Shi
Jun 1, 1997·The American Journal of Surgical Pathology·H R Harach, E D Williams
Mar 30, 1999·Gynecologic Oncology·D V HorbeltN J Walker-Bupp
Dec 24, 1997·The Journal of Investigative Dermatology·S M RudmanT Kealey

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