PMID: 8939463Nov 1, 1996Paper

Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds

Neurochemistry International
M NankaiC Carter

Abstract

NMDA increases the release of [14C]acetylcholine and [3H]spermidine or of [14C]GABA and [3H]dopamine from rat striatal slices. The pharmacology of these responses suggests that release of dopamine and GABA, acetylcholine, and spermidine is mediated, respectively, by three distinct NMDA receptor subtypes. IC50 values of compounds for the inhibition of dopamine and GABA release were closely matched, suggesting mediation by the same subtype. This receptor was generally more sensitive to all NMDA antagonists tested relative to that controlling acetylcholine or spermidine release (channel blockers, glycine antagonists, competitive antagonists and polyamine antagonists). The receptors controlling acetylcholine and spermidine release were characterised by lower antagonist sensitivity in general, and that controlling spermidine release was further defined by a marked insensitivity to ifenprodil, eliprodil, magnesium, dextromethorphan, dextrorphan, memantine, desipramine and polyamine spider toxins. In binding studies in which the displacement of 2 nM [3H]MK801 was studied in membranes prepared from a number of brain regions (in the presence of saturating concentrations of glutamate, glycine and spermidine) small regional differences in...Continue Reading

References

Jun 30, 1992·Biochemical and Biophysical Research Communications·H SugiharaS Nakanishi
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N NakanishiN A Shneider
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·G M DurandR S Zukin
Aug 31, 1992·Neuroscience Letters·M SchwarzK H Sontag
Sep 12, 1991·European Journal of Pharmacology·B EbertP Krogsgaard-Larsen
May 1, 1991·Journal of Neurochemistry·I J Reynolds, A M Palmer
Nov 7, 1991·Nature·K MoriyoshiS Nakanishi
Jul 9, 1990·Brain Research·B GottiB Scatton
Aug 21, 1990·European Journal of Pharmacology·R Trullas, P Skolnick
Aug 16, 1994·European Journal of Pharmacology·D J Laurie, P H Seeburg
Sep 8, 1994·Neuroreport·T PriestleyJ A Kemp
Feb 1, 1995·Journal of Neurochemistry·J ZhongP B Molinoff
Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·S Nakanishi, M Masu
Jun 7, 1993·FEBS Letters·M RaditschV Witzemann
Dec 15, 1993·The Journal of Comparative Neurology·M WatanabeM Mishina
Oct 1, 1993·Brain Research. Molecular Brain Research·J W Kusiak, D D Norton
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G M DurandR S Zukin

❮ Previous
Next ❯

Citations

Jul 18, 1996·European Journal of Pharmacology·M KlaricaC Carter
Nov 8, 2007·Journal of Neurochemistry·Martina FantinMichele Morari
Aug 16, 2016·Journal of Cardiovascular Pharmacology·Asya MakhroAnna Bogdanova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.